Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May 22;10(1):e41.
doi: 10.22037/aaem.v10i1.1597. eCollection 2022.

Safety and Adverse Events Related to COVID-19 mRNA Vaccines; a Systematic Review

SeyedAhmad SeyedAlinaghi  1 , Amirali Karimi  2 , Zahra Pashaei  1 , Arian Afzalian  2 , Pegah Mirzapour  1 , Kobra Ghorbanzadeh  3 , Afsaneh Ghasemzadeh  4 , Mohsen Dashti  4 , Newsha Nazarian  5 , Farzin Vahedi  2 , Marcarious M Tantuoyir  2   6 , Ahmadreza Shamsabadi  7 , Omid Dadras  1   8 , Esmaeil Mehraeen  9
Affiliations

Safety and Adverse Events Related to COVID-19 mRNA Vaccines; a Systematic Review

SeyedAhmad SeyedAlinaghi et al. Arch Acad Emerg Med. .

Abstract

Introduction: Knowledge of vaccine-related adverse events is crucial as they are among the most ‎important factors ‎that cause hesitation in receiving vaccines. Therefore, we aimed to systematically ‎review the adverse events ‎related to the mRNA vaccines reported in the literature.‎.

Method: A systematic literature search was carried out in the databases of Scopus, PubMed, ‎Cochrane, and Web ‎of Science. We selected original studies that explored the side effects of ‎mRNA ‎COVID-19 vaccines using a two-phase (title/abstract and full-text) screening process.‎.

Results: Cardiac ‎complications were the most commonly reported severe adverse events. It appeared that ‎systemic adverse reactions are more ‎common after the second dose of vaccines. The number of ‎adverse effects reported after the Pfizer vaccine was ‎higher than other vaccines, mostly due to its ‎earlier approval and more widespread use throughout the world. Cardiac adverse events had a ‎‎higher prevalence but no significant association has been found between COVID-19 mRNA vaccines ‎and cardiac ‎adverse events except for myopericarditis. ‎.

Conclusion: Vaccines ‎play a crucial role in controlling the COVID-19 pandemic and decreasing ‎mortalities and the results of the present ‎review acknowledge the fact that the benefits outweigh the ‎adverse events of these vaccines.‎.

Keywords: 2019-nCoV Vaccine mRNA-1273; Adverse effects; COVID-19 vaccines; BNT162 Vaccine; mRNA vaccines.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this manuscript.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the systematic review
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Amimo F, Lambert B, Magit A, Hashizume M. A review of prospective pathways and impacts of COVID-19 on the accessibility, safety, quality, and affordability of essential medicines and vaccines for universal health coverage in Africa. Globalization and health. 2021;17(1):42. - PMC - PubMed
    1. Gubernot D, Jazwa A, Niu M, Baumblatt J, Gee J, Moro P, et al. U. S. Population-Based background incidence rates of medical conditions for use in safety assessment of COVID-19 vaccines. Vaccine. 2021;39(28):3666–77. - PMC - PubMed
    1. Dadras O, Alinaghi SAS, Karimi A, MohsseniPour M, Barzegary A, Vahedi F, et al. Effects of COVID-19 prevention procedures on other common infections: a systematic review. European journal of medical research. 2021;26(1):67. - PMC - PubMed
    1. Joshi RK, Muralidharan CG, Gulati DS, Mopagar V, Dev JK, Kuthe S, et al. Higher incidence of reported adverse events following immunisation (AEFI) after first dose of COVID-19 vaccine among previously infected health care workers. Medical journal, Armed Forces India. 2021;77(Suppl 2):S505–s7. - PMC - PubMed
    1. Bukhari MH, Syed M, Zain S. The Differences between Traditional Vaccines and RNA Vaccines: Safety, Efficacy, Reliability and Future of COVID-19 Vaccines. Annals of King Edward Medical University Lahore Pakistan. 2021;27(2):172–82.

LinkOut - more resources