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Review
. 2022 Sep;44(5):625-648.
doi: 10.1007/s00281-022-00943-7. Epub 2022 Jun 29.

Inflammatory Responses After Ischemic Stroke

Jonathan Howard DeLong #  1 , Sarah Naomi Ohashi #  1 , Kevin Charles O'Connor  1 , Lauren Hachmann Sansing  2
Affiliations
Review

Inflammatory Responses After Ischemic Stroke

Jonathan Howard DeLong et al. Semin Immunopathol. 2022 Sep.

Abstract

Ischemic stroke generates an immune response that contributes to neuronal loss as well as tissue repair. This is a complex process involving a range of cell types and effector molecules and impacts tissues outside of the CNS. Recent reviews address specific aspects of this response, but several years have passed and important advances have been made since a high-level review has summarized the overall state of the field. The present review examines the initiation of the inflammatory response after ischemic stroke, the complex impacts of leukocytes on patient outcome, and the potential of basic science discoveries to impact the development of therapeutics. The information summarized here is derived from broad PubMed searches and aims to reflect recent research advances in an unbiased manner. We highlight valuable recent discoveries and identify gaps in knowledge that have the potential to advance our understanding of this disease and therapies to improve patient outcomes.

Keywords: Brain; Inflammation; Ischemic stroke; Leukocyte; Neurotoxic; Reparative.

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References

    1. Lindsay MP, Norrving B, Sacco RL, Brainin M, Hacke W, Martins S, Pandian J, Feigin V (2019) World Stroke Organization (WSO): Global Stroke Fact Sheet 2019. Int J Stroke 14:806–817 - PubMed - DOI
    1. Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV, American Heart Association Stroke Council, CoCS, Anesthesia, Council on Cardiovascular R, Intervention, Council on C, Stroke N, Council on E, Prevention, Council on Peripheral Vascular D, Council on Nutrition, PA, Metabolism (2013) An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44:2064–89 - PubMed - DOI
    1. Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA (2019) Ischaemic stroke. Nat Rev Dis Primers 5:70 - PubMed - DOI
    1. Rochmah TN, Rahmawati IT, Dahlui M, Budiarto W, Bilqis N (2021) Economic Burden of Stroke Disease: A Systematic Review. Int J Environ Res Public Health 18:7552
    1. Neumann J, Gunzer M, Gutzeit HO, Ullrich O, Reymann KG, Dinkel K (2006) Microglia provide neuroprotection after ischemia. Faseb j 20:714–716 - PubMed - DOI

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