Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 8;76(3):531-534.
doi: 10.1093/cid/ciac514.

Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Maura Manion  1 , Afroditi Boulougoura  1 , Nuha Naqvi  1 , Silvia Lucena Lage  1 , Elizabeth Richards  1 , Christopher Grivas  1 , Elizabeth Laidlaw  1 , Safia Kuriakose  2 , Ana M Ortega-Villa  1 , Saber Tadros  3 , Gregg Roby  1 , Adam Rupert  4 , France Galindo  1 , Megan Anderson  1 , Alice Pau  1 , George Deepe  5 , Virginia Sheikh  1 , Irini Sereti  1
Affiliations

Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome

Maura Manion et al. Clin Infect Dis. .

Abstract

In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.

Keywords: HIV/AIDS; IRIS; histoplasmosis.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. G. S. D. reports NIH funded grants NIH R01 AI 106269, NIH R01 AI 133797, and NIH R21 AI 160722. All other authors report no potential conflicts. erest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1.
Figure 1.
Patient comparisons. Abbreviations: CNS, central nervous system; GI, gastrointestinal; HC, healthy control; IFNγ, functional interferon γ; IL, interleukin; INF, interferon; IRIS, immune reconstitution inflammatory syndrome; LAN, lymphadenopathy; MAC, Mycobacterium avium complex; N/A, not applicable; TB, tuberculosis; tnfα, tumor necrosis factor alpha; VZV, varicella zoster virus.
See this image and copyright information in PMC

References

    1. Wheat J, Sarosi G, McKinsey D, et al. . Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America. Clin Infect Dis 2000; 30:688–95. - PubMed
    1. Hajjeh RA. Disseminated histoplasmosis in persons infected with human immunodeficiency virus. Clin Infect Dis 1995; 21(Suppl 1):S108–10. - PubMed
    1. Adenis AA, Valdes A, Cropet C, et al. . Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study. Lancet Infect Dis 2018; 18:1150–9. - PMC - PubMed
    1. Andrade BB, Singh A, Narendran G, et al. . Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome. PLoS Pathog 2014; 10:e1004433. - PMC - PubMed
    1. Barber DL, Mayer-Barber KD, Antonelli LR, et al. . Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice. Blood 2010; 116:3485–93. - PMC - PubMed

Publication types

MeSH terms