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. 2022 Jun 30;386(26):2528-2530.
doi: 10.1056/NEJMc2120183.

Detection of Marburg Virus Disease in Guinea

Fara R Koundouno  1 , Liana E Kafetzopoulou  2 , Martin Faye  3 , Annick Renevey  1 , Barrè Soropogui  4 , Kékoura Ifono  1 , Emily V Nelson  1 , Aly A Kamano  5 , Charles Tolno  6 , Giuditta Annibaldis  1 , Saa L Millimono  1 , Jacob Camara  4 , Karifa Kourouma  1 , Ahmadou Doré  4 , Tamba E Millimouno  1 , Fernand M B Tolno  1 , Julia Hinzmann  1 , Hugo Soubrier  1 , Mette Hinrichs  1 , Anke Thielebein  1 , Glaucia Herzer  1 , Meike Pahlmann  1 , Georges A Ki-Zerbo  5 , Pierre Formenty  7 , Anaïs Legand  7 , Michael R Wiley  8 , Ousmane Faye  3 , Moussa M Diagne  3 , Amadou A Sall  3 , Philippe Lemey  2 , Aïssatou Bah  4 , Stephan Günther  1 , Sakoba Keita  9 , Sophie Duraffour  10 , N'Faly Magassouba  11
Affiliations

Detection of Marburg Virus Disease in Guinea

Fara R Koundouno et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Map and timeline of events of the case occurrence (A) and phylogenetic analysis of MARV genomes (B)
(A) The top panel highlights the timeline of events while the map depicts parts of Guinea, Sierra Leone and Liberia with a focus on Forest Guinea and the Gueckédou prefecture where the MVD emerged. Note that on 3 September, LFHVG further shared the Marburg virus sequence with the public (https://virological.org/t/marburg-virus-sequence-from-guinea-2021/755) to support the public health response as well as the development and evaluation of Marburg virus disease diagnostics and therapeutics. The map depicts locations of the laboratory based in Gueckédou (LFHV-GKD), that of Conakry (LFHVG), and other relevant locations of sites that have reported (i) evidence of MARV circulation in bats and in humans in Sierra Leone, and (ii) identification of bat species known to be potential reservoir hosts of MARV in Guinea, including Méliandou, the location of the 2014-2016 Ebola virus disease outbreak, as well as Mongo Forest, Koundou Forest, Bakama cave, and Massif Ziama. The names and GPS locations of study sites from published works were used (Supplementary Appendix). The map was drawn using QGIS software version 3.22.0 and Adobe Illustrator®. Ct, cycle threshold; LFHV-GKD, “Laboratoire des Fièvres Hémorragiques Virales de Gueckédou”; LFHVG, “Laboratoire des Fièvres Hémorragiques Virales de la Guinée” ; IPD, “Institut Pasteur de Dakar”. (B) The map highlights four geographic regions of the African Union with known reports of MARV circulation (red, West Africa; green, East Africa; purple, Central Africa; dark blue, Southern Africa). This same color code is applied in the phylogenetic tree as per geographic origin of the sequence. Note that sequences in black refer to MARV cases that occurred outside Africa. The new Guinea MARV genome (MARV_GUI_2021, red and grey background, long branch) clusters between the Sierra Leone bat MARV clade (red) and the human Angola clade (blue). The internal node shapes are proportional to bootstrap support and accession numbers are provided. The accession numbers of the new MARV Guinea are OK665848 for LFHVG and OL702894 for IPD.
Figure 1
Figure 1. Map and timeline of events of the case occurrence (A) and phylogenetic analysis of MARV genomes (B)
(A) The top panel highlights the timeline of events while the map depicts parts of Guinea, Sierra Leone and Liberia with a focus on Forest Guinea and the Gueckédou prefecture where the MVD emerged. Note that on 3 September, LFHVG further shared the Marburg virus sequence with the public (https://virological.org/t/marburg-virus-sequence-from-guinea-2021/755) to support the public health response as well as the development and evaluation of Marburg virus disease diagnostics and therapeutics. The map depicts locations of the laboratory based in Gueckédou (LFHV-GKD), that of Conakry (LFHVG), and other relevant locations of sites that have reported (i) evidence of MARV circulation in bats and in humans in Sierra Leone, and (ii) identification of bat species known to be potential reservoir hosts of MARV in Guinea, including Méliandou, the location of the 2014-2016 Ebola virus disease outbreak, as well as Mongo Forest, Koundou Forest, Bakama cave, and Massif Ziama. The names and GPS locations of study sites from published works were used (Supplementary Appendix). The map was drawn using QGIS software version 3.22.0 and Adobe Illustrator®. Ct, cycle threshold; LFHV-GKD, “Laboratoire des Fièvres Hémorragiques Virales de Gueckédou”; LFHVG, “Laboratoire des Fièvres Hémorragiques Virales de la Guinée” ; IPD, “Institut Pasteur de Dakar”. (B) The map highlights four geographic regions of the African Union with known reports of MARV circulation (red, West Africa; green, East Africa; purple, Central Africa; dark blue, Southern Africa). This same color code is applied in the phylogenetic tree as per geographic origin of the sequence. Note that sequences in black refer to MARV cases that occurred outside Africa. The new Guinea MARV genome (MARV_GUI_2021, red and grey background, long branch) clusters between the Sierra Leone bat MARV clade (red) and the human Angola clade (blue). The internal node shapes are proportional to bootstrap support and accession numbers are provided. The accession numbers of the new MARV Guinea are OK665848 for LFHVG and OL702894 for IPD.
See this image and copyright information in PMC

References

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    1. Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371:1418–25. - PubMed
    1. Keita AK, Koundouno FR, Faye M, et al. Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks. Nature. 2021 - PubMed

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