Ventilation/perfusion mismatch is not the sole reason for hypoxaemia in early stage COVID-19 patients

doi:10.1183/16000617.0277-2021

Comment

. 2022 Jun 28;31(164):210277.

doi: 10.1183/16000617.0277-2021. Print 2022 Jun 30.

Ventilation/perfusion mismatch is not the sole reason for hypoxaemia in early stage COVID-19 patients

Gurgen Harutyunyan¹, Varsenik Harutyunyan², Garnik Harutyunyan², Andrés Sánchez Gimeno³, Artur Cherkezyan⁴, Spartak Petrosyan⁵, Anatoli Gnuni⁶, Suren Soghomonyan⁷

Affiliations

¹ Hospital 9 de Octubre, VITHAS, Emergency Dept, Valencia, Spain varsenik@hotmail.es.
² Universitat De València, Faculty of Pharmacy, Burjassot, Valencia, Spain.
³ Hospital 9 de Octubre, VITHAS, Emergency Dept, Valencia, Spain.
⁴ Erebouni medical center, Dept of Anesthesiology, Yerevan, Armenia.
⁵ National Center for Infection Diseases (Ministry of Health, Republic of Armenia), Yerevan, Armenia.
⁶ Ministry of Health, Republic of Armenia, Yerevan, Armenia.
⁷ The Ohio State University Wexner Medical Center, Columbus, OH, USA.

PMID: 35768132
PMCID: PMC9488915
DOI: 10.1183/16000617.0277-2021

Comment

Ventilation/perfusion mismatch is not the sole reason for hypoxaemia in early stage COVID-19 patients

Gurgen Harutyunyan et al. Eur Respir Rev. 2022.

. 2022 Jun 28;31(164):210277.

doi: 10.1183/16000617.0277-2021. Print 2022 Jun 30.

Authors

Gurgen Harutyunyan¹, Varsenik Harutyunyan², Garnik Harutyunyan², Andrés Sánchez Gimeno³, Artur Cherkezyan⁴, Spartak Petrosyan⁵, Anatoli Gnuni⁶, Suren Soghomonyan⁷

Affiliations

¹ Hospital 9 de Octubre, VITHAS, Emergency Dept, Valencia, Spain varsenik@hotmail.es.
² Universitat De València, Faculty of Pharmacy, Burjassot, Valencia, Spain.
³ Hospital 9 de Octubre, VITHAS, Emergency Dept, Valencia, Spain.
⁴ Erebouni medical center, Dept of Anesthesiology, Yerevan, Armenia.
⁵ National Center for Infection Diseases (Ministry of Health, Republic of Armenia), Yerevan, Armenia.
⁶ Ministry of Health, Republic of Armenia, Yerevan, Armenia.
⁷ The Ohio State University Wexner Medical Center, Columbus, OH, USA.

PMID: 35768132
PMCID: PMC9488915
DOI: 10.1183/16000617.0277-2021

Abstract

The transformation of alveolar microcirculation to a peripheral circulation type in COVID-19 patients leads to important decreases in haemoglobin–oxygen affinity and provokes biochemical shunt https://bit.ly/3jE53pe

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Conflict of interest statement

Conflicts of interest: All authors have nothing to disclose.

Comment on

COVID-19 pneumonia: pathophysiology and management.
Gattinoni L, Gattarello S, Steinberg I, Busana M, Palermo P, Lazzari S, Romitti F, Quintel M, Meissner K, Marini JJ, Chiumello D, Camporota L. Gattinoni L, et al. Eur Respir Rev. 2021 Oct 20;30(162):210138. doi: 10.1183/16000617.0138-2021. Print 2021 Dec 31. Eur Respir Rev. 2021. PMID: 34670808 Free PMC article. Review.

Cited by

Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?
Harutyunyan G, Benítez Bermejo RI, Harutyunyan V, Harutyunyan G, Sánchez Gimeno A, Cherkezyan A, Petrosyan S, Gnuni A, Soghomonyan S. Harutyunyan G, et al. Eur Respir Rev. 2022 Sep 20;31(165):220138. doi: 10.1183/16000617.0138-2022. Print 2022 Sep 30. Eur Respir Rev. 2022. PMID: 36130788 Free PMC article.
Multi-modal data combination strategy based on chest HRCT images and PFT parameters for intelligent dyspnea identification in COPD.
Yang Y, Chen Z, Li W, Zeng N, Guo Y, Wang S, Duan W, Liu Y, Chen H, Li X, Chen R, Kang Y. Yang Y, et al. Front Med (Lausanne). 2022 Dec 21;9:980950. doi: 10.3389/fmed.2022.980950. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36619622 Free PMC article.

References

1. Gattinoni L, Gattarello S, Steinberg I, et al. . COVID-19 pneumonia: pathophysiology and management. Eur Respir Rev 2021; 30: 210138. doi:10.1183/16000617.0138-2021 - DOI - PMC - PubMed
1. Donnellan ME. Capnography: gradient PACO2 and PETCO2. In: Esquinas AM, ed. Applied Technologies in Pulmonary Medicine. Basel, Karger, 2011; pp. 126–131.
1. Johan Petersson J, Glenny RW. Gas exchange and ventilation–perfusion relationships in the lung. Eur Respir J 2014; 44: 1023–1041. doi:10.1183/09031936.00037014 - DOI - PubMed
1. Lecompte-Osorio P, Pearson SD, Pieroni CH, et al. . Bedside estimates of dead space using end-tidal CO2 are independently associated with mortality in ARDS. Crit Care 2021; 25: 333. doi:10.1186/s13054-021-03751-x - DOI - PMC - PubMed
1. Viola L, Russo E, Benni M, et al. . Lung mechanics in type L COVID-19 pneumonia: a pseudo-normal ARDS. Transl Med Commun 2020; 5: 27. doi:10.1186/s41231-020-00076-9 - DOI - PMC - PubMed

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[1] Gattinoni L, Gattarello S, Steinberg I, et al. . COVID-19 pneumonia: pathophysiology and management. Eur Respir Rev 2021; 30: 210138. doi:10.1183/16000617.0138-2021 - DOI - PMC - PubMed

[2] Gattinoni L, Gattarello S, Steinberg I, et al. . COVID-19 pneumonia: pathophysiology and management. Eur Respir Rev 2021; 30: 210138. doi:10.1183/16000617.0138-2021 - DOI - PMC - PubMed

[3] Donnellan ME. Capnography: gradient PACO2 and PETCO2. In: Esquinas AM, ed. Applied Technologies in Pulmonary Medicine. Basel, Karger, 2011; pp. 126–131.

[4] Donnellan ME. Capnography: gradient PACO2 and PETCO2. In: Esquinas AM, ed. Applied Technologies in Pulmonary Medicine. Basel, Karger, 2011; pp. 126–131.

[5] Johan Petersson J, Glenny RW. Gas exchange and ventilation–perfusion relationships in the lung. Eur Respir J 2014; 44: 1023–1041. doi:10.1183/09031936.00037014 - DOI - PubMed

[6] Johan Petersson J, Glenny RW. Gas exchange and ventilation–perfusion relationships in the lung. Eur Respir J 2014; 44: 1023–1041. doi:10.1183/09031936.00037014 - DOI - PubMed

[7] Lecompte-Osorio P, Pearson SD, Pieroni CH, et al. . Bedside estimates of dead space using end-tidal CO2 are independently associated with mortality in ARDS. Crit Care 2021; 25: 333. doi:10.1186/s13054-021-03751-x - DOI - PMC - PubMed

[8] Lecompte-Osorio P, Pearson SD, Pieroni CH, et al. . Bedside estimates of dead space using end-tidal CO2 are independently associated with mortality in ARDS. Crit Care 2021; 25: 333. doi:10.1186/s13054-021-03751-x - DOI - PMC - PubMed

[9] Viola L, Russo E, Benni M, et al. . Lung mechanics in type L COVID-19 pneumonia: a pseudo-normal ARDS. Transl Med Commun 2020; 5: 27. doi:10.1186/s41231-020-00076-9 - DOI - PMC - PubMed

[10] Viola L, Russo E, Benni M, et al. . Lung mechanics in type L COVID-19 pneumonia: a pseudo-normal ARDS. Transl Med Commun 2020; 5: 27. doi:10.1186/s41231-020-00076-9 - DOI - PMC - PubMed

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Ventilation/perfusion mismatch is not the sole reason for hypoxaemia in early stage COVID-19 patients

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Ventilation/perfusion mismatch is not the sole reason for hypoxaemia in early stage COVID-19 patients

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