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Comment
. 2022 Jun 29;7(1):204.
doi: 10.1038/s41392-022-01061-4.

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Emma Morrish  1   2   3 , Jürgen Ruland  4   5   6   7
Affiliations
Comment

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Emma Morrish et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Activation of thymus derived cytotoxic FCER1G+ αβILTCKs in cancer tissue. FCER1G-expressing αβ TCR lineage innate-like T cells with high cytotoxic potential (αβILTCKs) are an evolutionarily conserved innate-type T cell that develops from a unique thymic progenitor. These FCER1G+ αβILTCKs are distinct from conventional PD-1+CD8+ cytotoxic T cells (CTLs) and reactive to unmutated self (tumour) antigen. Their intratumoural recruitment, local expansion and effector function is driven by tumour-elicited IL-15 production. For details see text. IL-15R IL-15 receptor, FCER1G Fc Epsilon Receptor Ig, TCR T cell receptor, MHC-I major histocompatibility complex class I. Created with Biorender.com
See this image and copyright information in PMC

Comment on

  • Programme of self-reactive innate-like T cell-mediated cancer immunity.
    Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ, Kansler ER, Steele M, Han J, Shyu A, Zhang J, Stamatiades EG, Liu M, Li S, Do MH, Edwards C, Kang DS, Chen CT, Wei IH, Pappou EP, Weiser MR, Garcia-Aguilar J, Smith JJ, Leslie CS, Li MO. Chou C, et al. Nature. 2022 May;605(7908):139-145. doi: 10.1038/s41586-022-04632-1. Epub 2022 Apr 20. Nature. 2022. PMID: 35444279 Free PMC article.

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