Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 May 26:3:889879.
doi: 10.3389/falgy.2022.889879. eCollection 2022.

Adult Food Protein-Induced Enterocolitis Syndrome

Sara Anvari  1   2 , Melanie A Ruffner  3   4
Affiliations
Review

Adult Food Protein-Induced Enterocolitis Syndrome

Sara Anvari et al. Front Allergy. .

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE, cell-mediated food allergy, commonly diagnosed in infants and young children. In recent years, new-onset adult FPIES has been recognized. The underlying pathogenic mechanism of FPIES has yet to be elucidated, thus disease-specific diagnostic biomarkers have yet to be determined and an oral food challenge (OFC) remains the gold-standard for the diagnosis. Pediatric patients with FPIES classically present with symptoms of delayed, repetitive vomiting approximately 1 to 4 hours following ingestion of a food allergen. However, adults with FPIES have been reported to have a different symptom profile and different food triggers compared to the pediatric FPIES population. The current FPIES diagnostic criteria may not be appropriate for the diagnosis of adult FPIES patients, thus an oral food challenge remains a diagnostic tool. This review provides an overview of the current literature on the clinical presentation, epidemiology, diagnosis, triggers and management of adult FPIES.

Keywords: adult food allergy; food allergy; food protein-induced enterocolitis syndrome; gastrointestinal allergy; non-IgE allergy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Nowak-Wegrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. (2017) 139:1111–26.e4. 10.1016/j.jaci.2016.12.966 - DOI - PubMed
    1. Lee E, Campbell DE, Barnes EH, Mehr SS. Resolution of acute food protein- induced enterocolitis syndrome in children. JACI In Practice. (2017) 5:486–8.e1. 10.1016/j.jaip.2016.09.032 - DOI - PubMed
    1. Katz Y, Goldberg MR, Rajuan N, Cohen A, Leshno M. The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: a large-scale, prospective population-based study. J Allergy Clin Immunol. (2011) 127:647–53.e1–3. 10.1016/j.jaci.2010.12.1105 - DOI - PubMed
    1. Powell GK. Milk- and soy-induced enterocolitis of infancy. Clinical features and standardization of challenge. J Pediatr. (1978) 93:553–60. 10.1016/S0022-3476(78)80887-7 - DOI - PubMed
    1. Powell GK. Food protein-induced enterocolitis of infancy: differential diagnosis and management. Compr Ther. (1986) 12:28–37. - PubMed

LinkOut - more resources