Principal components analysis for source localization of VEPs in man

Abstract

This study defines and compares the topologies of the visual evoked potentials to various stimuli such as pattern onset/offset, pattern reversal, pattern motion and high frequency luminance flicker. The responses recorded from 24 occipital derivations were examined using a three sphere conductance model to represent the head, with the assumption that activity from an underlying cortical source is equivalent to a single dipole. Principal components analysis was used to find the dimensionality of the data space. From this analysis could be concluded that all stimuli evoked responses in the primary visual cortex. Only pattern onset, and to a lesser degree pattern offset and pattern reversal, yielded activity in higher visual areas. In particular it has been shown that the CI, CII interval of the pattern onset response has its origins in two different cortical regions. A fast positive (CI)-negative (part of the CII) component arises from area 18 (or 19), a slower negative (initial part of CII) component comes from area 17.