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. 2022 Jun 13:9:915152.
doi: 10.3389/fmed.2022.915152. eCollection 2022.

Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis

Jianhua Yang  1 , Mengyao Liu  2 , Shu Wang  1 , Yuanxiu Gan  1 , Xiangyu Chen  3 , Yang Tao  1 , Junwei Gao  4
Affiliations

Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis

Jianhua Yang et al. Front Med (Lausanne). .

Abstract

Introduction: Resistin is a small secretory adipokine which is implicated to obesity and associated diseases. Recently, plenty of research papers have been conducted to explore the association between peripheral resistin and the severity of acute pancreatitis (AP). However, the results were controversial. In this study, we aimed to confirm the effect of peripheral resistin and the development of acute pancreatitis.

Methods: A comprehensive online search was performed using the PubMed, Embase, Web of Science, CNKI, and Wanfang databases up through January 20, 2022. The retrieved records and their references were screened to identify additional studies. Data were extracted to calculate the pooled Hedges' g and its 95% CI, which were selected to assess peripheral resistin levels and the severity of acute pancreatitis. Subgroup analyses, sensitivity analyses, meta-regression, and publication bias tests were also undertaken based on obtained information.

Results: A total of eleven studies with 892 acute pancreatitis patients were enrolled in the study. Peripheral resistin levels were significantly increased in severe acute pancreatitis compared with mild acute pancreatitis (Hedges' g = 2.092, 95% CI: 0.994-3.190, P < 0.001). Subgroup analyses based on sample types and ethnicity also showed similar results. A single study did not affect our results, which was verified by sensitivity analysis. Meta-regression analyses revealed that age, gender of the included subjects, sample size, and publication year did not moderate effects on the present results.

Conclusion: In our study, peripheral resistin levels were significantly elevated in patients with severe AP compared with patients with mild AP. Abnormal resistin levels may provide us some new insights in predicting the severity of AP.

Keywords: acute pancreatitis; association; plasma; resistin; serum.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study identification.
Figure 2
Figure 2
Forest plot for the random-effect meta-analysis.
Figure 3
Figure 3
Forest plot for the random-effect meta-analysis of the serum subgroup.
Figure 4
Figure 4
Forest plot for the random-effect meta-analysis of the Chinese subgroup.
Figure 5
Figure 5
Galbraith plot for the random-effect meta-analysis.
Figure 6
Figure 6
Forest plot for the fixed-effect meta-analysis after removing the studies outside the boundaries of the Galbraith plot.
Figure 7
Figure 7
(A–D) Meta-regression in all studies.
Figure 8
Figure 8
Sensitivity analysis.
Figure 9
Figure 9
Funnel plot of precision using Hedges' g statistics.
See this image and copyright information in PMC

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