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Meta-Analysis
. 2022 Jan-Dec:21:15330338221109798.
doi: 10.1177/15330338221109798.

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Md Abdul Aziz  1 , Tahmina Akter  2   3 , Mohammad Safiqul Islam  2   3
Affiliations
Meta-Analysis

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Md Abdul Aziz et al. Technol Cancer Res Treat. 2022 Jan-Dec.

Abstract

Background:MiR-196a2 rs11614913 polymorphism has been studied in a wide range of cancers throughout the years. Despite a large number of epidemiological studies performed in almost all ethnic populations, the contribution of this polymorphism to cancer risk is still inconclusive. Therefore, this updated meta-analysis was performed to estimate a meticulous correlation between miR-196a2 rs11614913 variant and cancer susceptibility. Methods: A systematic study search was carried out using PubMed, ScienceDirect, CNKI, EMBASE, Scopus, and Google Scholar databases following PRISMA guidelines to find necessary literature up to December 15, 2021. Pooled odds ratios with corresponding 95% confidence intervals were estimated using RevMan 5.4 based on ethnicities, cancer types, control sources, and genotyping methods. Results: A total of 152 studies, including 120 135 subjects (53 818 patients and 66 317 controls; 140 studies, after removing studies that deviated from HWE: 51 459 cases and 62 588 controls), were included in this meta-analysis. Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05). It is also observed from ethnicity-based subgroup analysis that rs11614913 polymorphism is significantly (P < .05) linked with cancer in the Asian (in CDM2, CDM3, RM, AM) and the African population (in CDM1, CDM3, ODM). Stratified analysis based on the cancer types demonstrated a significantly decreased correlation for breast, hepatocellular, lung, and gynecological cancer and an increased association for oral and renal cell cancer. Again, the control population-based subgroup analysis reported a strongly reduced correlation for HB population in CDM2, RM, and AM. A substantially decreased risk was also observed for other genotyping methods in multiple genetic models. Conclusions:MiR-196a2 rs11614913 variant is significantly correlated with overall cancer susceptibility. Besides, rs11614913 is correlated with cancer in Asians and Africans. It is also correlated with breast, gynecological, hepatocellular, lung, oral, and renal cell cancer.

Keywords: MiR-196a2; cancer; meta-analysis; miRNAs; polymorphism.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Study selection process according to PRISMA guidelines.
Figure 2.
Figure 2.
Ethnicity-based forest plot indicating the connection of miR-196a2 rs11614913 polymorphism with overall cancer susceptibility in the allele model (AM).
Figure 3.
Figure 3.
Forest plot in allele model (AM) indicating the connection of miR-196a2 rs11614913 polymorphism with cancer types.
Figure 4.
Figure 4.
Funnel plots indicating the publication bias for detecting the connection of miR-196a2 rs11614913 polymorphism with overall cancer susceptibility.
Figure 5.
Figure 5.
Sensitivity plot in allele model (AM) for detecting the connection of miR-196a2 rs11614913 polymorphism and overall cancer.
See this image and copyright information in PMC

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