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Review
. 2022 Aug;26(16):4389-4400.
doi: 10.1111/jcmm.17473. Epub 2022 Jun 29.

circRNA: Regulatory factors and potential therapeutic targets in inflammatory dermatoses

Ruifeng Liu  1 , Luyao Zhang  2 , Xincheng Zhao  1 , Jia Liu  1 , Wenjuan Chang  1 , Ling Zhou  1 , Kaiming Zhang  1
Affiliations
Review

circRNA: Regulatory factors and potential therapeutic targets in inflammatory dermatoses

Ruifeng Liu et al. J Cell Mol Med. 2022 Aug.

Abstract

The skin is the largest organ of the human body and acts as the first line of defence against injury and infection. Skin diseases are among the most common health problems and are associated with a considerable burden that encompasses financial, physical and mental consequences for patients. Exploring the pathogenesis of skin diseases can provide insights into new treatment strategies. Inflammatory dermatoses account for a large proportion of dermatoses and have a great impact on the patients' body and quality of life. Therefore, it is important to study their pathogenesis and explore effective treatment. Circular RNAs (circRNAs) are a special type of RNA molecules that play important regulatory roles in several diseases and are involved in skin pathophysiological processes. This review summarizes the biogenesis, properties and functions of circRNAs as well as their roles in the pathogenesis of inflammatory dermatoses, including psoriasis, lupus erythematosus, atopic dermatitis, lichen planus and severe acne and their potential as therapeutic targets.

Keywords: circRNA; dermatoses; inflammation; skin.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Biogenesis of circRNA. (A) Lariat‐driven circularization. The pre‐mRNA is folded and spliced, resulting in exon‐skipping, followed by removal or retention of the introns to form ecircRNA or EIciRNA. (B) Intron‐pairing‐driven circularization. Base pairing of long flanking complementary introns next to the exons is circularized to form ecircRNA or EIciRNA. (C) RBP‐driven circularization. RBPs binding to sequence motifs of flanking introns interact with each other to form a bridge to facilitate circularization, leading to the formation of ecircRNA or EIciRNA. D. Biogenesis of ciRNAs. The 7nt GU‐rich element at the 5′‐end (black circle) and the 11nt C‐rich element at the 3′‐end (red circle) help intron lariats escape debranching and become stable ciRNAs
FIGURE 2
FIGURE 2
Regulatory network of circRNAs, their associated miRNAs and target genes in the pathogenesis of psoriasis. S‐MSCs, skin mesenchymal stem cells
See this image and copyright information in PMC

References

    1. Li F, Yang Q, He AT, Yang BB. Circular RNAs in cancer: limitations in functional studies and diagnostic potential. Semin Cancer Biol. 2021;75:49‐61. - PubMed
    1. Bei Y, Yang T, Wang L, et al. Circular RNAs as potential Theranostics in the cardiovascular system. Mol Ther Nucleic Acids. 2018;13:407‐418. - PMC - PubMed
    1. Yan L, Chen YG. Circular RNAs in immune response and viral infection. Trends Biochem Sci. 2020;45(12):1022‐1034. - PMC - PubMed
    1. Diener TO. Potato spindle tuber “virus”. IV. A replicating, low molecular weight RNA. Virology. 1971;45(2):411‐428. - PubMed
    1. Weiner AJ, Choo QL, Wang KS, et al. A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta. J Virol. 1988;62(2):594‐599. - PMC - PubMed

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