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. 2022 Jul 15;24(27):4892-4895.
doi: 10.1021/acs.orglett.2c01714. Epub 2022 Jun 30.

Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044

Tatyana N Makarieva  1 , Lyudmila A Romanenko  1 , Konstantin S Mineev  2   3   4 , Larisa K Shubina  1 , Elena B Guglya  2   3 , Natalia I Kalinovskaya  1 , Natalia V Ivanchina  1 , Alla G Guzii  1 , Olga A Belozerova  2   3 , Sergey I Kovalchuk  3 , Roman S Popov  1 , Vladimir A Denisenko  1 , Valery V Mikhailov  1 , Vladislav V Babenko  5 , Elena N Ilina  5 , Maja V Malakhova  5 , Stanislav S Terekhov  3 , Arsen M Kudzhaev  3 , Pavel S Dmitrenok  1 , Ilia V Yampolsky  2   3 , Valentin A Stonik  1
Affiliations

Streptocinnamides A and B, Depsipeptides from Streptomyces sp. KMM 9044

Tatyana N Makarieva et al. Org Lett. .

Abstract

The bacterium Streptomyces sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A (1) and B (2), representatives of a new structural group of antibiotics. The structures of 1 and 2 were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits Micrococcus sp. KMM 1467, Arthrobacter sp. ATCC 21022, and Mycobacterium smegmatis MC2 155.

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