Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2022 Nov;36(11):e876-e879.
doi: 10.1111/jdv.18386. Epub 2022 Jul 10.

Cutaneous adverse reactions following SARS-CoV-2 vaccine booster dose: a real-life multicentre experience

G Avallone #  1 , F Cavallo #  1 , C Astrua  1 , G Caldarola  2 , C Conforti  3 , C De Simone  2   4 , N di Meo  3 , A di Stefani  2 , G Genovese  5   6 , C A Maronese  5   6 , A V Marzano  5   6 , R Parente  7 , P Quaglino  1 , G Roccuzzo  1 , F Tassone  2 , I Zalaudek  3 , R Senetta #  8 , S Ribero #  1
Affiliations
Multicenter Study

Cutaneous adverse reactions following SARS-CoV-2 vaccine booster dose: a real-life multicentre experience

G Avallone et al. J Eur Acad Dermatol Venereol. 2022 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
(a) erythematous macules and papules on the back, right flank and abdomen (b) Mild spongiosis, apoptotic keratinocytes and interface change. Moderate perivascular lymphocytic infiltrate and dermal papillary oedema consistent with maculopapular rash. (H&E, magnification 20×) (c) erythematous‐violaceous patches of the toes (d) histopathological findings diagnostic for chilblain‐like lesions: vacuolar interface changes with occasional necrotic keratinocytes and smudging of the basement membrane. Papillary dermal oedema, extravasated erythrocytes and mainly perivascular lymphomonocytic infiltrates. (H&E, magnification 200×) (e) Erythematous patches with central blisters in the interdigital folds of the hand. (f) Histology revealing erythema multiforme‐like changes: apoptotic keratinocytes with confluent necrosis and detachment of the overlying epidermal layers, vacuolar interface changes and mild superficial dermal perivascular lymphocytic infiltrate with vessel ectasia and some pigment incontinence (H&E, magnification 200×) (g) erythematous‐violaceous hyperkeratotic patch of the heel (h) histopathological findings diagnostic for chilblain‐like lesions: parakeratosis with serum exudate and apoptotic keratinocytes in the epidermis, vacuolar degeneration of the dermal–epidermal junction with thickening of the basement membrane, papillary oedema and a mainly lymphocytic vasculitis with swollen endothelium and fibrin deposits in the dilated vessels (H&E, magnification 200×).
See this image and copyright information in PMC

Comment in

References

    1. Callaway E. COVID vaccine boosters: the most important questions. Nature 2021; 596: 178–180. - PubMed
    1. Spitzer A, Angel Y, Marudi O et al. Association of a Third Dose of BNT162b2 vaccine with incidence of SARS‐CoV‐2 infection among health Care Workers in Israel. JAMA 2022; 327: 341–349. - PMC - PubMed
    1. Avallone G, Quaglino P, Cavallo F et al. SARS‐CoV‐2 vaccine‐related cutaneous manifestations: a systematic review [published online ahead of print, 2022 Feb 9]. Int J Dermatol 2022. 10.1111/ijd.16063 - DOI - PMC - PubMed
    1. Vizcarra P, Haemmerle J, Velasco H et al. BNT162b2 mRNA COVID‐19 vaccine reactogenicity: the key role of immunity. Vaccine 2021; 39: 7367–7374. - PMC - PubMed
    1. Stuart ASV, Shaw RH, Liu X et al. Immunogenicity, safety, and reactogenicity of heterologous COVID‐19 primary vaccination incorporating mRNA, viral‐vector, and protein‐adjuvant vaccines in the UK(com‐COV2): a single‐blind, randomised, phase 2, non‐inferiority trial. Lancet 2022; 399: 36–49. - PMC - PubMed