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Review
. 2022:2514:107-120.
doi: 10.1007/978-1-0716-2403-6_11.

Histochemical Staining of Vasculogenic Mimicry

Saber Imani  1   2 , Shuya Liu  1 , Mazaher Maghsoudloo  3 , QingLian Wen  4
Affiliations
Review

Histochemical Staining of Vasculogenic Mimicry

Saber Imani et al. Methods Mol Biol. 2022.

Abstract

Vasculogenic mimicry (VM) describes a new tumor microvascular paradigm of non-endothelial cells, where aggressive cancer cells independent of angiogenesis acquire the ability to fluid-conducting vessels. VM shows worse 5-year overall survival in cancer that suggesting that VM could be a promising surgical and effective adjuvant therapy strategy in prognostics of metastatic cancer patients. The current chapter is a comprehensive review on "Main Staining Methods and Protocols in Vasculogenic Mimicry." Here, we provide most up-to-date and detailed information upon microscopy and histology protocols for the identification and understanding of VM process in both in vitro and in vivo.

Keywords: Diagnosis; Endothelial markers; Immunohistochemistry; Malignancy; Paraffin-embedded tissue specimens; Periodic acid; Schiff; Vasculogenic mimicry.

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References

    1. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013 - DOI - PubMed
    1. Qiao L, Liang N, Zhang J (2015) Advanced research on vasculogenic mimicry in cancer. J Cell Mol Med 19:315–326. https://doi.org/10.1016/j.cell.2011.02.013 - DOI - PubMed - PMC
    1. Folberg R, Hendrix MJ, Maniotis AJ (2000) Vasculogenic mimicry and tumor angiogenesis. Am J Pathol 156:361–381. https://doi.org/10.1016/S0002-9440(10)64739-6 - DOI - PubMed - PMC
    1. Feng Y, Wang B, Liang G et al (2015) Relationship between vasculogenic mimicry and clinic pathological features in laryngeal carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 29:2071–2075 - PubMed
    1. Shirakawa K, Kobayashi H, Heike Y et al (2002) Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft. Cancer Res 62:560–566 - PubMed

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