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Review
. 2022 Oct;74(5):847-858.
doi: 10.1007/s43440-022-00377-w. Epub 2022 Jun 30.

Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions

Nadia Sawicka-Gutaj #  1 , Natalia Zawalna #  2 , Paweł Gut  2 , Marek Ruchała  2
Affiliations
Review

Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions

Nadia Sawicka-Gutaj et al. Pharmacol Rep. 2022 Oct.

Abstract

Thyroid hormones (THs) play an important role in the regulation of energy metabolism. They also take part in processes associated with the central nervous system (CNS), including survival and differentiation of neurons and energy expenditure. It has been reported that a correlation exists between the functioning of the thyroid gland and the symptoms of CNS such as cognitive impairment, depression, and dementia. Literature data also indicate the influence of THs on the pathogenesis of CNS diseases, such as Alzheimer's disease, epilepsy, depression, and Parkinson's disease. This review describes the relationship between THs and metabolism in the CNS, the effect of THs on the pathological conditions of the CNS, and novel options for treating these conditions with TH derivatives.

Keywords: Central nervous system; Hyperthyroidism; Hypothyroidism; Metabolism; Thyroid hormones.

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