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. 2022 Jul;9(7):e546.
doi: 10.1016/S2352-3026(22)00037-0.

Idiopathic multicentric Castleman disease with arteriolar endotheliopathy and secondary haemophagocytosis

Christine M Campbell  1 , Daniel R Owen  2 , Amanallah Montazeripouragha  1 , Iain McCormick  1 , David C Fajgenbaum  3 , Luke Y C Chen  4
Affiliations

Idiopathic multicentric Castleman disease with arteriolar endotheliopathy and secondary haemophagocytosis

Christine M Campbell et al. Lancet Haematol. 2022 Jul.
No abstract available

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Conflict of interest statement

Declaration of interests We declare no competing interests.

Figures

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Excisional biopsy of cervical lymph node showing increased vascularity and polyclonal plasmacytosis. The histologic findings are in keeping with idiopathic multicentric Castleman disease. H&E, original magnification 100X.
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Excisional biopsy of cervical lymph node showing regressed germinal center (red arrow). H&E, original magnification 200X.
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Excisional biopsy of cervical lymph node showing polyclonal plasmacytosis. H&E, original magnification 400X.
Figure:
Figure:. Liver biopsy demonstrating reactive arteriolar endothelium in TAFRO and reactive hemophagocytosis.
The portal tracts (A) contain reactive arteriolar endothelium (black arrows) and normal portal vein endothelium (blue arrow). H&E, original magnification 400X.Core needle biopsy of liver showing reactive hemophagocytosis by sinusoidal Kupffer cells (B).
Figure:
Figure:. Liver biopsy demonstrating reactive arteriolar endothelium in TAFRO and reactive hemophagocytosis.
The portal tracts (A) contain reactive arteriolar endothelium (black arrows) and normal portal vein endothelium (blue arrow). H&E, original magnification 400X.Core needle biopsy of liver showing reactive hemophagocytosis by sinusoidal Kupffer cells (B).
See this image and copyright information in PMC

MeSH terms

Supplementary concepts