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Review
. 2022 Sep:187:63-74.
doi: 10.1016/j.brainresbull.2022.06.014. Epub 2022 Jun 28.

Nervous system manifestations related to COVID-19 and their possible mechanisms

Zhen Xie  1 , Hao Hui  2 , Zhihan Zhao  3 , Wenjin Yu  4 , Rui Wu  5 , Yanzhao Zhu  3 , Yuan Song  3 , Bingqing Cao  6 , Wenzhen Shi  7 , Di Zhao  5 , Yunsong Zhao  5 , Junchao Lv  5 , Qian Yao  3 , Yan Duan  3 , Jingwen Li  8 , Haijun Zhang  5 , Linfu Zhou  3 , Xiaotian Wang  9 , Ye Tian  10 , Gang Zhao  11
Affiliations
Review

Nervous system manifestations related to COVID-19 and their possible mechanisms

Zhen Xie et al. Brain Res Bull. 2022 Sep.

Abstract

In December 2019, the novel coronavirus disease (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection broke. With the gradual deepening understanding of SARS-CoV-2 and COVID-19, researchers and clinicians noticed that this disease is closely related to the nervous system and has complex effects on the central nervous system (CNS) and peripheral nervous system (PNS). In this review, we summarize the effects and mechanisms of SARS-CoV-2 on the nervous system, including the pathways of invasion, direct and indirect effects, and associated neuropsychiatric diseases, to deepen our knowledge and understanding of the relationship between COVID-19 and the nervous system.

Keywords: CNS; COVID-19; Neuroinvasion; Neurology; Neuropsychiatry; PNS; SARS-CoV-2.

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Conflict of interest statement

The authors declare no commercial or financial conflict of interests.

Figures

Fig. 1
Fig. 1
The mechanism of SARS affecting the nervous system SARS-COV-2 directly infects the nervous system: (1) Virus-infected binding sites in thenervous system, (2) Neuronal retrograde dissemination, (3) Damage to the BBB and endothelial system,(4) Gastrointestinal route.
Fig. 2
Fig. 2
COVID related disease.
See this image and copyright information in PMC

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