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Review
. 2022 Aug;36(4):729-744.
doi: 10.1016/j.hoc.2022.03.006. Epub 2022 Jun 27.

Genome-Edited T Cell Therapies

Giorgio Ottaviano  1 , Waseem Qasim  2
Affiliations
Review

Genome-Edited T Cell Therapies

Giorgio Ottaviano et al. Hematol Oncol Clin North Am. 2022 Aug.

Abstract

Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing platforms have been used to address human leukocyte antigen (HLA) barriers to generate universal CAR-T cell therapy and early applications have been reported in children and adults against B cell malignancies. Recently developed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based systems and related technologies offer the prospect of enhanced cellular immunotherapies for a wider range of hematological malignancies.

Keywords: Base editor; CRISPR/Cas9; Chimeric antigen receptor; Cytidine deamination; Genome editing; T cell therapies.

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