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Randomized Controlled Trial
. 2022 Apr;76(2):108-114.
doi: 10.5455/medarh.2022.76.108-114.

The Moisturizing Efficacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period

Tarik Catic  1 , Belma Pehlivanovic  2 , Nejla Pljakic  1 , Amina Balicevac  1
Affiliations
Randomized Controlled Trial

The Moisturizing Efficacy of a Proprietary Dermo-Cosmetic Product( CLS02021) Versus Placebo in a 4-week Application Period

Tarik Catic et al. Med Arch. 2022 Apr.

Abstract

Background: Studies suggest that applying probiotic skincare products may have beneficial effects on the skin due to bacteria competitiveness and specific metabolites produced by probiotics. The cream CLS02021 is a postbiotic blend of metabolites, including organic acids, enzymes, and peptides that are a result of the co-fermentation of three proprietary probiotic strains and is specific for its high concentration of the enzyme Sphingomyelinase which plays a significant role in cell signaling pathways and ceramide production.

Objective: The aim of this study is to evaluate the cosmetic effects of probiotic-derived Ingredient CLS02021 and its safety in healthy volunteers.

Methods: Fifty healthy volunteers between 18 and 69 years old were recruited to participate in this multicentric, randomized, intra-individual, double-blind group study. Following a face-split design, volunteers applied both face cream containing CLS02021 on one side of their face and a placebo cream on the other side of their face for a total duration of four weeks, two times a day. Evaluation of the cosmetic effects included instrument measurements of moisturizing, elasticity, wrinkle depth, sebum production, pore size, melanin production, sensitivity, and side effects.

Results: A significant difference of CLS02021 over the placebo group was observed for moisture and elasticity increase (both p<0.001), pore size (p<0.01), and a wrinkle depth decrease (p<0.05). No significant differences were noted in sebum production, melanin level, skin cleanliness, and sensitivity between groups.

Conclusion: CLS02021, as a probiotic-derived ingredient, showed strong beneficial effects on skin moisture and elasticity increase, wrinkle depth, and pore size reduction. Face cream containing CLS02021 is well tolerated and could be an organic choice for cosmetic hydrating and antiaging skincare treatment.

Keywords: antiaging; cosmetic product; probiotics; skin care.

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Conflict of interest statement

None declared.

Figures

Graph 1.
Graph 1.. Comparison of mean values at point Wo, W2 and W4 for moisture (A), elasticity (B), pore size (C) and Wrinkle depth (D)
See this image and copyright information in PMC

References

    1. Dréno B, Araviiskaia E, Berardesca E, Gontijo G, Sanchez Viera M, Xiang LF, Martin R, Bieber T. Microbiome in healthy skin, update for dermatologists. J Eur Acad Dermatol Venereol. 2016;30(12):2038–2047. doi: 10.1111/jdv.13965. - DOI - PMC - PubMed
    1. Lynde CW, Andriessen A, Bertucci V, McCuaig C, Skotnicki S, Weinstein M, Wiseman M, Zip C. The Skin Microbiome in Atopic Dermatitis and Its Relationship to Emollients. J Cutan Med Surg. 2016;20(1):21–28. doi: 10.1177/1203475415605498. - DOI - PubMed
    1. Picardo M, Ottaviani M. Skin microbiome and skin disease: the example of rosacea. J Clin Gastroenterol. 2014;48(Suppl 1):S85–86. doi: 10.1097/MCG.0000000000000241. - DOI - PubMed
    1. Lew LC, Liong MT. Bioactives from probiotics for dermal health: functions and benefits. Journal of Applied Microbiology. 2013;114(5):1241–1253. - PubMed
    1. Di Marzio L, Centi C, Cinque B, Masci S, Giuliani M, Arcieri A, Zicari L, De Simone C, Cifone MG. Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. Exp Dermatol. 2003;12(5):615–620. - PubMed

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