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Review
. 2022 Jun 14:13:894814.
doi: 10.3389/fphar.2022.894814. eCollection 2022.

Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine

Ishani Chakrabartty  1 , Yugal Kishore Mohanta  1 , Amilia Nongbet  2 , Tapan Kumar Mohanta  3 , Saurov Mahanta  4 , Nibedita Das  2 , Muthupandian Saravanan  5 , Nanaocha Sharma  6
Affiliations
Review

Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine

Ishani Chakrabartty et al. Front Pharmacol. .

Abstract

In the current scenario, cardiovascular disease (CVD) is one of the most life-threatening diseases that has caused high mortality worldwide. Several scientists, researchers, and doctors are now resorting to medicinal plants and their metabolites for the treatment of different diseases, including CVD. The present review focuses on one such family of medicinal plants, called Lamiaceae, which has relieving and preventive action on CVD. Lamiaceae has a cosmopolitan distribution and has great importance in the traditional system of medicine. Lamiaceae members exhibit a wide range of activities like antioxidant, antihyperlipidemic, vasorelaxant, and thrombolytic effect, both in vitro and in vivo-these are mechanisms that contribute to different aspects of CVD including stroke, heart attack, and others. These plants harbour an array of bioactive compounds like phenolic acids, flavonoids, alkaloids, and other phytochemicals responsible for these actions. The review also highlights that these plants are a rich source of essential nutrients and minerals like omega-3 and hence, can serve as essential sources of functional foods-this can have an additional role in the prevention of CVDs. However, limitations still exist, and extensive research needs to be conducted on the Lamiaceae family in the quest to develop new and effective plant-based drugs and functional foods that can be used to treat and prevent cardiovascular diseases worldwide.

Keywords: CVD; Lamiaceae; ethnopharmacology; functional food; medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Worldwide exploration of Lamiaceae for ethnopharmacological evaluations and other use. (Figure Source: The Authors and the figure is made using ArcGIS Pro software).
FIGURE 2
FIGURE 2
Exploration of Lamiaceae bioactive natural products on CVD (Figure Made in BioRender.com).
FIGURE 3
FIGURE 3
Bioactive compounds from Lamiaceae that can be derived as potential lead drugs for the treatment of CVDs (Biovia software was used to prepare chemical structures https://www.3ds.com/products-services/biovia/products/scientific-informatics/biovia-draw/).
FIGURE 4
FIGURE 4
Schematic representation of the mechanism of action of the bioactive compounds of Lamiaceae in the treatment of CVDs (Figure made in Microsoft paint).
FIGURE 5
FIGURE 5
Potential exploration of Lamiaceae as a cardioprotective functional foods (Figure Made in BioRender.com).
See this image and copyright information in PMC

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