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Review
. 2022 May 29;14(5):e25460.
doi: 10.7759/cureus.25460. eCollection 2022 May.

Incidence Trends and Epidemiology of Staphylococcus aureus Bacteremia: A Systematic Review of Population-Based Studies

Joya-Rita Hindy  1 , Juan A Quintero-Martinez  1 , Alexander T Lee  2 , Christopher G Scott  2 , Danielle J Gerberi  3 , Maryam Mahmood  1 , Daniel C DeSimone  1 , Larry M Baddour  1
Affiliations
Review

Incidence Trends and Epidemiology of Staphylococcus aureus Bacteremia: A Systematic Review of Population-Based Studies

Joya-Rita Hindy et al. Cureus. .

Abstract

Objectives: To determine incidence trends of Staphylococcus aureus bacteremia (SAB) from population-based studies from multiple countries.

Methods: A contemporary systematic review was conducted using Ovid Cochrane Central Register of Controlled Trials (1991+), Ovid Embase (1974+), Ovid Medical Literature Analysis and Retrieval System Online (MEDLINE) (1946+ including epub ahead of print, in-process & other non-indexed citations), and Web of Science Core Collection (Science Citation Index Expanded 1975+ and Emerging Sources Citation Index 2015+). Two authors (J.R.H. and J.A.Q.M.) independently reviewed all studies and included those that reported population-based incidence of SAB in patients aged 18 years and older.

Results: Twenty-six studies met inclusion criteria with the highest number (n=6) of studies conducted in Canada. The incidence of SAB ranged from 9.3 to 65 cases/100,000/year. The median age of patients with SAB ranged from 62 to 72 years and SAB cases were more commonly observed in men than in women. The most common infection sources were intravascular catheters and skin and soft tissue infections. SAB incidence trends demonstrated high variability for geographic regions and calendar years. Overall, there was no change in the incidence trend across all studies during the past two decades.

Conclusion: Multiple factors, both pros, and cons are likely responsible for the overall stable SAB incidence in countries included in this systematic review. Some of these factors vary in geographic location and prompt additional investigations from countries not included in the current review so that a more global characterization is defined.

Keywords: bacteremia; incidence; population-based study; staphylococcus aureus; trends.

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Conflict of interest statement

The authors have declared financial relationships, which are detailed in the next section.

Figures

Figure 1
Figure 1. Flow diagram of study selection per 2020 PRISMA guidelines
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Figure 2
Figure 2. Geographical representation of the 11 countries included in the systematic review
Figure 3
Figure 3. Incidence rate per 100,000/year in included studies
*The multinational study included five countries: Australia, Canada, Denmark, Finland, and Sweden
Figure 4
Figure 4. Overall incidence trend of SAB in included studies
SAB: Staphylococcus aureus bacteremia *The multinational study included five countries: Australia, Canada, Denmark, Finland, and Sweden.
Figure 5
Figure 5. Web of Science core collection via Clarivate Analytics (Science Citation Index Expanded 1975+ and Emerging Sources Citation Index 2015+)
See this image and copyright information in PMC

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