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Case Reports
. 2022 Jan-Dec:21:23259582221109567.
doi: 10.1177/23259582221109567.

Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic Challenge

Nina Yancheva  1 , Dimitar Strashimirov  1 , Dragomir Dardanov  2 , Bojidar Kamenov  3 , Atanas Radinoff  4
Affiliations
Case Reports

Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic Challenge

Nina Yancheva et al. J Int Assoc Provid AIDS Care. 2022 Jan-Dec.

Abstract

Non-Langerhans cell histiocytosis is a rare disease which seldom affects adults. We report a case of a 32-year-old Bulgarian woman living with HIV. She developed severe anemia, extreme splenomegaly, requiring splenectomy and vertebral tumor formations leading to fracture. The diagnosis was confirmed by histological examination of the spleen, but subsequently questioned and a cumulative disease was discussed. After genetic testing, a cumulative disease was ruled out and the condition was determined to be Non-Langerhans cell histiocytosis. According to literature data, the disease has a high mortality rate. However, in our case, we should also note that there was a delay in diagnosis by several months due to difficulties in the clarification of the hematological disorder.

Keywords: ART; Erdheim-Chester disease; Europe; HIV.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
MRI revealed tumor formation and fracture of the 9th vertebra.
Figure 2.
Figure 2.
MRI revealed tumor formations of the 6th thoracic and first lumbar vertebrae.
See this image and copyright information in PMC

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