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Review
. 2022 Jul 1;93(3):e2022141.
doi: 10.23750/abm.v93i3.12577.

Neonatal septic shock, a focus on first line interventions

Valentina Spaggiari  1 , Erica Passini  2 , Sara Crestani  3 , Maria Federica Roversi  4 , Luca Bedetti  5 , Katia Rossi  6 , Laura Lucaccioni  7 , Cecilia Baraldi  8 , Elisa Della Casa Muttini  9 , Licia Lugli  10 , Lorenzo Iughetti  11 , Alberto Berardi  12
Affiliations
Review

Neonatal septic shock, a focus on first line interventions

Valentina Spaggiari et al. Acta Biomed. .

Abstract

Septic shock is a main cause of morbidity and mortality in neonates. Septic shock evolves from compensated to uncompensated through 3 distinct phases. Prompt diagnosis is challenging, since neonatal septic shock may overlap with the physiological changes occurring at birth. The outcome of septic shock depends on a prompt recognition of symptoms and a strict adherence to cardiopulmonary resuscitation guidelines. Fluid administration plays a major role in the initial management of septic shock. If there is no response to volume filling, inotropes must be infused within one hour of onset (dopamine, dobutamine, adrenaline). Life-threatening infections require immediate and aggressive empiric use of antimicrobials. In the pediatric age, delay in antibiotic initiation for treating septic shock is associated with poor outcome and increased risk of mortality. There is a gap regarding first line interventions in neonatal septic shock. This review addresses initial interventions in the treatment of neonatal septic shock and discusses currently available evidences., These interventions may allow to improve the outcome if they are promptly carried out.

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Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article

Figures

Figure 1.
Figure 1.
Initial steps in the treatment of septic shock in the newborn (modified from Ref. 30)
See this image and copyright information in PMC

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