Chromatin Remodeling Factors Drive Epigenetic Changes Crucial for T-cell Exhaustion

No authors listed

Comment

No authors listed. Cancer Discov. 2022.

. 2022 Aug 5;12(8):1837.

doi: 10.1158/2159-8290.CD-RW2022-121.

Abstract

Depleting components of the cBAF chromatin remodeling complex improves antitumor T-cell function.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence.
Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. Belk JA, et al. Cancer Cell. 2022 Jul 11;40(7):768-786.e7. doi: 10.1016/j.ccell.2022.06.001. Epub 2022 Jun 23. Cancer Cell. 2022. PMID: 35750052 Free PMC article.