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Meta-Analysis
. 2022 Sep;32(9):3088-3103.
doi: 10.1007/s11695-022-06121-w. Epub 2022 Jul 1.

The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Zeinab Mokhtari  1 , Elham Hosseini  1 , Marsa Zaroudi  2 , Deanna L Gibson  3 , Azita Hekmatdoost  4 , Marjan Mansourian  5 , Amin Salehi-Abargouei  6 , Zahra Faghihimani  1 , Gholamreza Askari  7
Affiliations
Meta-Analysis

The Effect of Vitamin D Supplementation on Serum 25-Hydroxy Vitamin D in the Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-Analysis of Randomized Clinical Trials

Zeinab Mokhtari et al. Obes Surg. 2022 Sep.

Abstract

Currently, there is no consensus on the optimal vitamin D administration in bariatric patients. The present systematic review and meta-analysis were conducted to examine the effect of vitamin D supplements on serum level of 25(OH) vitamin D in the patients undergoing bariatric surgery (BS).Random model effects were used to estimate standardized mean difference (SMD) with a 95% confidence interval (CI). Nine clinical trials were included in the meta-analysis. Vitamin D supplementation in patients undergoing BS modestly improves vitamin D status (SMD, 0.53; 95% CI, 0.28, 0.77) particularly, in the dosages above 2850 IU/day and in the patients with BMI greater than 50 kg/m2. Vitamin D supplementation was associated with prevention of raising of the PTH serum concentration and without impact on serum calcium levels.

Keywords: Bariatric surgery; Gastric bypass; PTH; RYGB; Sleeve gastrectomy; Vitamin D.

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