Androgen effects cause sex-biased impairment of CD8+ T cell antitumor activity
- PMID: 35776801
- DOI: 10.1126/sciimmunol.abq6783
Androgen effects cause sex-biased impairment of CD8+ T cell antitumor activity
Abstract
Androgen signaling compromises CD8+ T cell effector functions and contributes to sex-biased outcomes in many forms of cancer (see the related Research Article by Kwon et al.).
Comment on
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Androgen receptor activity in T cells limits checkpoint blockade efficacy.Nature. 2022 Jun;606(7915):791-796. doi: 10.1038/s41586-022-04522-6. Epub 2022 Mar 23. Nature. 2022. PMID: 35322234 Free PMC article.
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Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer.Sci Immunol. 2022 Jul;7(73):eabq2630. doi: 10.1126/sciimmunol.abq2630. Epub 2022 Jul 1. Sci Immunol. 2022. PMID: 35420889 Free PMC article.
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