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Review
. 2022 Oct:74:101655.
doi: 10.1016/j.trim.2022.101655. Epub 2022 Jun 28.

The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients

Maryam Rahimi Foroudi  1 , Ramin Yaghobi  2 , Afsoon Afshari  3 , Jamshid Roozbeh  3 , Seyed Mohsen Miresmaeili  1 , Amaneh Javid  4
Affiliations
Review

The effect of BK polyomavirus large T antigen on CD4 and CD8 T cells in kidney transplant recipients

Maryam Rahimi Foroudi et al. Transpl Immunol. 2022 Oct.

Abstract

Human BK polyomavirus (BKPyV) can affect the machinery of the host cell to induce optimal viral replication or transform them into tumor cells. Reactivation of BKPyV happens due to immunosuppression therapies following renal transplantation which might result in BK polyomavirus nephropathy (BKPyVAN) and allograft loss. The first protein that expresses after entering into host cells and has an important role in pathogenicity is the Large T antigen (LT-Ag). In this review tries to study the molecular and cellular inter-regulatory counteractions especially between CD4 and CD8 T cells, and BKPyV LT-Ag may have role in nephropathy after renal transplantation.

Keywords: BK polyomavirus; CD4 T cells; CD8 T cells; Kidney transplantation; Large T antigen.

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