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. 2022 Sep;19(9):553-554.
doi: 10.1038/s41575-022-00652-4.

Sudden onset hepatitis in children

Deirdre A Kelly  1   2 , Zania Stamataki  3
Affiliations

Sudden onset hepatitis in children

Deirdre A Kelly et al. Nat Rev Gastroenterol Hepatol. 2022 Sep.

Abstract

The recent increase in unexplained acute hepatitis in children in 2022 has focused attention on acute paediatric liver disease. We discuss emerging evidence and leading causal hypotheses in context with potential long-term effects of the COVID-19 pandemic for young children.

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Conflict of interest statement

D.A.K. is a member of the UK Health Security Agency (UKHSA) technical expert panel. Z.S. collaborates with AstraZeneca, UK, as principal investigator and lead supervisor for a Medical Research Council Industrial Cooperative Awards in Science & Technology (MRC iCASE) PhD studentship.

Figures

Fig. 1
Fig. 1. Unexplained sudden onset hepatitis in children in the UK.
Disease progression and liver sequelae in acute hepatitis in children. ALT, alanine transaminase; AST, aspartate transaminase; WHO, World Health Organization.
See this image and copyright information in PMC

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