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. 2023 Jan;36(1):199-202.
doi: 10.1007/s40620-022-01374-1. Epub 2022 Jul 2.

Impact of low eGFR on the immune response against COVID-19

Arturo Blazquez-Navarro #  1   2 , Lisa Mittmann #  3 , Constantin Joachim Thieme  2   4 , Moritz Anft  1 , Krystallenia Paniskaki  1 , Adrian Doevelaar  1 , Felix Sebastian Seibert  1 , Bodo Hoelzer  1 , Margarete Justine Konik  3 , Marc Moritz Berger  5 , Thorsten Brenner  5 , Clemens Tempfer  6 , Carsten Watzl  7 , Toni Luise Meister  8 , Stephanie Pfaender  8 , Eike Steinmann  8 , Sebastian Dolff  3 , Ulf Dittmer  9 , Oliver Witzke  3 , Ulrik Stervbo  1 , Toralf Roch  1   2 , Michal Or-Guil  2 , Timm Henning Westhoff  1 , Nina Babel  10   11   12
Affiliations

Impact of low eGFR on the immune response against COVID-19

Arturo Blazquez-Navarro et al. J Nephrol. 2023 Jan.
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Patients in the Low-eGFR sub-cohort demonstrated an altered immune system. The figure depicts the levels of circulating immune subsets at the initial and follow-up visit (a–f), as well as the changes in serum cytokines between the two visits (g–m). For the immune subsets, peripheral blood from 57 patients, 41 from the Normal-eGFR sub-cohort (blue) and 16 from the Low-eGFR sub-cohort (red) was characterized. The figure depicts the frequencies of circulating lymphocytes (a), neutrophils (b), terminally differentiated T cells (c, d) and T cells specific against the viral spike antigen (e–f) using multiparametric flow cytometry. The P values were calculated controlling for differences in age and Charlson comorbidity index (see Statistical methods). In all cases, the left boxplots show the data for the initial visit, while the right boxplots depict the data at follow-up. The area shaded in grey represents the reference range for each parameter, if applicable. For the cytokine kinetics (g–m), 74 patients were analysed, 61 Low-eGFR sub-cohort (red) and 13 Normal-eGFR sub-cohort (blue). The figure shows the change in cytokine levels between initial and follow-up for each patient, where a negative value means a decrease in concentration and vice versa. A dashed grey line marks the threshold of a null change between the visits. Importantly, the P value does not refer to a comparison between the two sub-cohorts, but to the significance of the change in cytokine concentrations within each sub-cohort. eGFR estimated glomerular filtration rate; IFN interferon; IL interleukin; MCP monocyte chemoattractant protein
See this image and copyright information in PMC

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