Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Aug:53S:S171-S173.
doi: 10.1016/j.carrev.2022.06.008. Epub 2022 Jun 10.

Protamine-induced Acute Thrombosis in a Post-TAVR Patient: A Word of Caution

Akhil S Kallur  1 , Sukhdeep Bhogal  2 , Ron Waksman  3 , Nelson L Bernardo  2
Affiliations
Case Reports

Protamine-induced Acute Thrombosis in a Post-TAVR Patient: A Word of Caution

Akhil S Kallur et al. Cardiovasc Revasc Med. 2023 Aug.

Abstract

Major vascular complications after transcatheter aortic valve replacement (TAVR) are a pertinent issue and associated with increased morbidity and mortality. We herein describe a case of acute limb ischemia following the administration of protamine sulfate (PS) that was administered to mitigate a bleeding complication post-failure of a vascular access closure device. PS should be used cautiously for the prevention or management of bleeding-site complications following TAVR. The patient described in this case has consented to having his case described in this manuscript.

Keywords: Acute limb ischemia; Bleeding; Protamine sulfate; Thrombosis; Transcatheter aortic valve replacement.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ron Waksman – Advisory Board: Abbott Vascular, Boston Scientific, Medtronic, Philips IGT, Pi-Cardia Ltd.; Consultant: Abbott Vascular, Biotronik, Boston Scientific, Cordis, Medtronic, Philips IGT, Pi-Cardia Ltd., Swiss Interventional Systems/SIS Medical AG, Transmural Systems Inc., Venous MedTech; Grant Support: AstraZeneca, Biotronik, Boston Scientific, Chiesi, Medtronic, Philips IGT; Speakers Bureau: AstraZeneca; Investor: MedAlliance, Transmural Systems Inc. All other authors – None.

Publication types

LinkOut - more resources