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. 2022 Jul 2;27(1):106.
doi: 10.1186/s40001-022-00733-9.

Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke

Kai-Bin Lin #  1   2 , Feng-Hua Fan #  1   3 , Ming-Qi Cai  1 , Yin Yu  1 , Chuan-Liang Fu  4 , Lu-Yue Ding  4 , Yu-Dong Sun  4 , Jia-Wen Sun  5 , Yong-Wang Shi  6 , Zhi-Feng Dong  1 , Min-Jie Yuan  1 , Shuai Li  1 , Yan-Peng Wang  1 , Kan-Kai Chen  1 , Ji-Ni Zhu  1 , Xin-Wei Guo  1 , Xue Zhang  1 , Yu-Wu Zhao  7 , Jing-Bo Li  8 , Dong Huang  9
Affiliations

Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke

Kai-Bin Lin et al. Eur J Med Res. .

Abstract

Background: Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel and convenient measurements that are positively associated with body inflammation. However, little is known regarding the association between SIII/SIRI with the presence of AF among the patients with ischemic stroke.

Methods: A total of 526 ischemic stroke patients (173 with AF and 353 without AF) were consecutively enrolled in our study from January 2017 to June 2019. SIII and SIRI were measured in both groups. Logistic regression analysis was used to analyse the potential association between SIII/SIRI and the presence of AF. Finally, the correlation between hospitalization expenses, changes in the National Institutes of Health Stroke Scale (NIHSS) scores and SIII/SIRI values were measured.

Results: In patients with ischemic stroke, SIII and SIRI values were significantly higher in AF patients than in non-AF patients (all p < 0.001). Moreover, with increasing quartiles of SIII and SIRI in all patients, the proportion of patients with AF was higher than that of non-AF patients gradually. Logistic regression analyses demonstrated that log-transformed SIII and log-transformed SIRI were independently associated with the presence of AF in patients with ischemic stroke (log-transformed SIII: odds ratio [OR]: 1.047, 95% confidence interval CI = 0.322-1.105, p = 0.047; log-transformed SIRI: OR: 6.197, 95% CI = 2.196-17.484, p = 0.001). Finally, a positive correlation between hospitalization expenses, changes in the NIHSS scores and SIII/SIRI were found, which were more significant in patients with AF (all p < 0.05).

Conclusions: Our study suggests SIII and SIRI are convenient and effective measurements for predicting the presence of AF in patients with ischemic stroke. Moreover, they were correlated with increased financial burden and poor short-term prognosis in AF patients presenting with ischemic stroke.

Keywords: Atrial fibrillation; Ischemic stroke; Systemic immune inflammation index; Systemic inflammation response index.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of patient enrolment in our study. AF, atrial fibrillation
Fig. 2
Fig. 2
Distribution of proportions in atrial fibrillation (AF) and non-AF subgroups among different quartiles of the systemic immune inflammation index (SIII) (A) and system inflammation response index (SIRI) (B) in patients with stroke
Fig. 3
Fig. 3
Correlation between costs and systemic immune inflammation index (SIII) (or system inflammation response index [SIRI]). SIII and SIRI were logarithmically transformed before plotting. Hollow circles and dotted lines, non-atrial fibrillation (AF) patients (n = 353); Filled circles and solid lines, patients with AF (n = 173)
Fig. 4
Fig. 4
Correlation between change in National Institutes of Health Stroke Scale (NIHSS) scores and systemic immune inflammation index (SIII) (or system inflammation response index [SIRI]). SIII and SIRI were logarithmically transformed before plotting. Hollow circles and dotted lines, non-atrial fibrillation (AF) patients (n = 353); Filled circles and solid lines, patients with AF (n = 173)
See this image and copyright information in PMC

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