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. 2022 Jun;14(2):155-161.
doi: 10.52054/FVVO.14.2.026.

Effect of vaginal/oral tadalafil on endometrial thickness in IVF patients: a double-blind, placebo controlled RCT: a pilot study

J Balduyck, A Ameye, W Decleer

Effect of vaginal/oral tadalafil on endometrial thickness in IVF patients: a double-blind, placebo controlled RCT: a pilot study

J Balduyck et al. Facts Views Vis Obgyn. 2022 Jun.

Abstract

Objective: To investigate the effect of tadalafil (a long working phosphodiesterase type 5 inhibitor) on the endometrial thickness, biochemical pregnancy rates and clinical pregnancy rates in women in an in vitro fertilization treatment. This study investigates the use of vaginal and oral administration of tadalafil.

Study design: This is a prospective double-blind placebo-controlled randomized controlled trial with 58 patients in an in vitro fertilization treatment with a short antagonist stimulation protocol. The study population is divided into three equal groups comparing oral and vaginal administration of tadalafil to a control group.

Results: No significant difference in endometrial thickness and number of biochemical and clinical pregnancies was found between the three groups.

Conclusion: This study could not show a significant benefit of administration of tadalafil. However, a trend towards more pregnancies in the group treated with oral tadalafil is seen, more research in specific subgroups is needed.

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Figures

Figure 1
Figure 1
Simplified pathway of PDE. PDE = phosphodiesterase, (c)GMP = (cyclic) guanosine monophosphate, MLC(-P) = myosin light chain (-phosphate).
Figure 2
Figure 2
Study protocol. rFSH = recombinant follicular stimulating hormone, GnRH = gonadotropin-releasing hormone, hCG = human chorion gonadotrophin (ovulation trigger), OR = oocyte retrieval, ET = embryo transfer.
Figure 3
Figure 3
Flow diagram.
See this image and copyright information in PMC

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