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Case Reports
. 2022 Jun 25:42:101030.
doi: 10.1016/j.gore.2022.101030. eCollection 2022 Aug.

Massive hypertriglyceridemia associated with paclitaxel; a case report

Anojian Koneshamoorthy  1 , Danielle Hulse  1 , Chia Yuen Chong  2 , Balasubramanian Krishnamurthy  1   3 , Sumitra Ananda  2   4   5   6 , Peter S Hamblin  1   6
Affiliations
Case Reports

Massive hypertriglyceridemia associated with paclitaxel; a case report

Anojian Koneshamoorthy et al. Gynecol Oncol Rep. .

Abstract

This report describes a patient who developed massive hypertriglyceridemia (12,488 mg/dL or 141 mmol/L) during paclitaxel and carboplatin adjuvant chemotherapy for high grade serous fallopian tube carcinoma. Paclitaxel was thought to be the causative agent and she had normal triglyceride levels following a change to carboplatin and gemcitabine. To our knowledge, this is the highest reported triglyceride level associated with paclitaxel. Measurement of serum lipids should be considered in individuals receiving taxane chemotherapy, especially in those with type 2 diabetes mellitus or a history of dyslipidemia.

Keywords: Fallopian tube carcinoma; Hypertriglyceridemia; Paclitaxel.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Time course of serum triglyceride concentrations. Orange arrows represent each cycle of carboplatin/paclitaxel chemotherapy. Green arrows represent each cycle of carboplatin/gemcitabine. Red line represents normal upper limit of serum triglyceride concentration of 150 mg/dL (1.7 mmol/L).
See this image and copyright information in PMC

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