Innovations in Immunosuppression for Intestinal Transplantation

Abstract

It has been 57 years since the first intestinal transplant. An increased incidence of graft rejection has been described compared to other solid organ transplants due to high immunogenicity of the bowel, which in health allows the balance between of dietary antigen with defense against pathogens. Expanding clinical experience, knowledge of gastrointestinal physiology and immunology have progress post-transplant immunosuppressive drug regimens. Current regimes aim to find the window between prevention of rejection and the risk of infection (the leading cause of death) and malignancy. The ultimate aim is to achieve graft tolerance. In this review we discuss advances in mucosal immunology and technologies informing the development of new anti-rejection strategies with the hope of improved survival in the next generation of transplant recipients.

Keywords: bowel transplant; immunosuppression; intestinal failure; parenteral nutrition; tissue engineering.

Figure 1

Summary of pathways targeted by current and new approaches to immunosuppression in intestinal transplant (not to scale).