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. 2022 Jun 15:14:935841.
doi: 10.3389/fnagi.2022.935841. eCollection 2022.

Impact of Parkinson's Disease on Functional Mobility at Different Stages

Sara Mollà-Casanova  1 , Jose Pedrero-Sánchez  2 , Marta Inglés  1 , Juan López-Pascual  2 , Elena Muñoz-Gómez  1 , Marta Aguilar-Rodríguez  1 , Nuria Sempere-Rubio  1 , Pilar Serra-Añó  1
Affiliations

Impact of Parkinson's Disease on Functional Mobility at Different Stages

Sara Mollà-Casanova et al. Front Aging Neurosci. .

Abstract

Introduction: Specific functional assessments to determine the progression of Parkinson's Disease (PD) are important to slow down such progression and better plan rehabilitation. This study aimed to explore possible differences in the performance of different functional tasks included in a mobility test using sensors embedded in an Android device, in people at different PD stages.

Materials and methods: Eighty-seven participants with PD agreed to participate in this cross-sectional study. They were assessed once using an inertial sensor and variables related to functional status were recorded (i.e., MLDisp, APDisp, DispA, Vrange, MLRange, PTurnSit, PStand, TTime, and RTime).

Results: There was significant impairment of the vertical range during gait between stages I and II. Further, when stages II and III were compared, the sit-to-stand power was significantly impaired, and the total time required to complete the test increased significantly (p < 0.05). Even more significant differences were obtained when stages I and III were compared, in particular, dysfunction in postural control, vertical range, sit to stand power and total time. Finally, there were no significant differences between stages in the medial-lateral displacements and reaction time (p > 0.05).

Conclusion: Functional mobility becomes more significantly impaired in the PD population as the PD stages progress. This implies impaired postural control, decreased ability to sit down or stand up from a chair, increased metabolic cost during walking, and overall slowing-down of motor function.

Keywords: FallSkip; Hoen and Yahr stages; Parkinson’s disease; functional assessment; severity of Parkinson’s.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor, declared a shared affiliation with several of the authors SM-C, MI, EM-G, MA-R, NS-R, and PS-A, at the time of review.

Figures

FIGURE 1
FIGURE 1
Set up of Fallskip device.
FIGURE 2
FIGURE 2
FallSkip protocol.
See this image and copyright information in PMC

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