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Review
. 2022 Jun 16:13:907605.
doi: 10.3389/fimmu.2022.907605. eCollection 2022.

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era

Collin J Larkin  1 , Víctor A Arrieta  1   2   3 , Hinda Najem  1   2 , Gongbo Li  1   2 , Peng Zhang  1   2 , Jason Miska  1   2 , Peiwen Chen  1   2 , Charles David James  1   2 , Adam M Sonabend  1   2 , Amy B Heimberger  1   2
Affiliations
Review

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era

Collin J Larkin et al. Front Immunol. .

Abstract

The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors. Single cell analysis techniques such as single cell genomic and transcriptomic sequencing analysis are on the rise and play an important role in elucidating the glioma TME. These large datasets will prove useful for patient tumor characterization, including immune configuration that will ultimately influence therapeutic choices and especially immune therapies. In this review we discuss the advantages and drawbacks of these techniques while debating their role in the domain of glioma-infiltrating myeloid cells characterization and function.

Keywords: glioblastoma; immunotherapy; macrophage; single cell analysis; spatial analysis; transcriptomics; tumor microenvironment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary schematic detailing sources of samples, analytical techniques, and potential uses of data from single-cell technologies to improve and devise novel immune therapeutics. Specifically, single-cell technologies can be implemented in clinical studies for biomarker discovery, characterization of novel drug targets, and the study of pharmacodynamic effects of therapies in window-of-opportunity clinical trials. Created with BioRender.
See this image and copyright information in PMC

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