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. 2022 Jun 15:13:898072.
doi: 10.3389/fphar.2022.898072. eCollection 2022.

Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity

Marija Zdravkovic  1   2 , Viseslav Popadic  1 , Slobodan Klasnja  1 , Natasa Milic  3   4 , Nina Rajovic  3 , Anica Divac  1 , Andrea Manojlovic  1 , Novica Nikolic  1 , Filip Lukic  1 , Esma Rasiti  1 , Katarina Mircetic  1 , Djordje Marinkovic  1 , Sofija Nikolic  1 , Bogdan Crnokrak  1   2 , Danica Popovic Lisulov  1 , Sinisa Djurasevic  5 , Maja Stojkovic  6 , Zoran Todorovic  1   2 , Ratko Lasica  2   7 , Biljana Parapid  2   7 , Predrag Djuran  1 , Milica Brajkovic  1
Affiliations

Obstructive Sleep Apnea and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation, and Obesity

Marija Zdravkovic et al. Front Pharmacol. .

Abstract

Introduction: The present study aimed to establish the role of lipid abnormalities and inflammatory markers for developing cardiovascular risk, as well as to address the importance of obesity as a common comorbidity in patients with obstructive sleep apnea (OSA). Methods: The study was conducted as a prospective cohort study including 120 patients with newly diagnosed OSA between 2019 and 2020, at University Clinical Hospital Center "Bezanijska kosa", Belgrade, Serbia. The diagnosis was established by polysomnography. In all patients, sociodemographic data, respiratory, lipid, and inflammatory parameters were collected and complete echocardiographic study and 24-h blood pressure monitoring were performed. Results: The mean patient age was 55.7 ± 13.8 years. Study population was mostly male (70.0%) and obese (56.7%). At least 30 apneas or hypopneas per hour were present in 39.0% of patients. A strong positive correlation was found between OSA severity and BMI (r = 0.562, p < 0.001), both associated with lipid, inflammatory and respiratory parameters, and cardiovascular profile of patients with OSA (p < 0.05 for all). Echocardiographic study and 24-h blood pressure monitoring parameters were in turn correlated with lipid and inflammatory markers (p < 0.05 for all). Conclusion: The results of this study support the important role of dyslipidemia and inflammation, as well as coexistence of obesity in the pathogenesis of numerous conditions linked with an increased risk of cardiovascular morbidity and mortality in patients with OSA.

Keywords: cardiovascular risk; dyslipidemia; echocardiography; inflammation; obstructive sleep apnea.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Correlation between AHI and BMI
FIGURE 2
FIGURE 2
Correlation between tryglicerides, HDL and cardiovascular parameters.
FIGURE 3
FIGURE 3
Correlation between CRP, ESR and cardiovascular parameters.
See this image and copyright information in PMC

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