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. 2022 Jun 16:13:857449.
doi: 10.3389/fphar.2022.857449. eCollection 2022.

Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders

Shun Zhu  1 , Fang Liu  1 , Ruiyuan Zhang  1 , Zongxiang Xiong  1 , Qian Zhang  1 , Li Hao  2 , Shiyin Chen  3
Affiliations

Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders

Shun Zhu et al. Front Pharmacol. .

Abstract

In recent years, neurological diseases including Alzheimer's disease, Parkinson's disease and stroke are one of the main causes of death in the world. At the same time, the incidence of psychiatric disorders including depression and anxiety has been increasing. Accumulating elderly and stressed people suffer from these brain disorders, which is undoubtedly a huge burden on the modern aging society. Neolignans, the main active ingredients in Magnolia officinalis cortex, were reported to have neuroprotective effects. In addition, the key bioactive ingredients of neolignans, magnolol (1) and honokiol (2), were proved to prevent and treat neurological diseases and psychiatric disorders by protecting nerve cells and brain microvascular endothelial cells (BMECs). Furthermore, neolignans played a role in protecting nerve cells via regulation of neuronal function, suppression of neurotoxicity, etc. This review summarizes the neuroprotective effect, primary mechanisms of the leading neolignans and provides new prospects for the treatment of brain disorders in the future.

Keywords: Magnolia officinalis; brain disorders; multiple pathways; neolignans; neuroprotective effect.

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Conflict of interest statement

HSY was employed by Pharmaceutical Group Co., LTD. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures of magnolol and honokiol.
FIGURE 2
FIGURE 2
Mechanisms involved in the regulation of neuronal function by neolignans.
FIGURE 3
FIGURE 3
Mechanisms involved in the reduction of neurotoxicity by neolignans.
FIGURE 4
FIGURE 4
Mechanisms involved in the suppression of apoptosis by neolignans.
FIGURE 5
FIGURE 5
Mechanisms involved in the anti-inflammatory by neolignans.
FIGURE 6
FIGURE 6
Mechanisms involved in the anti-oxidation by neolignans.
FIGURE 7
FIGURE 7
Mechanisms involved in the protection of BMECs by neolignans.
See this image and copyright information in PMC

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