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Review
. 2022 Oct 12;28(57):e202201499.
doi: 10.1002/chem.202201499. Epub 2022 Aug 10.

Current State of [Fe]-Hydrogenase and Its Biomimetic Models

Chao Wang  1 , Zhenli Lai  2 , Gangfeng Huang  2 , Hui-Jie Pan  1
Affiliations
Review

Current State of [Fe]-Hydrogenase and Its Biomimetic Models

Chao Wang et al. Chemistry. .

Abstract

[Fe]-hydrogenase, the third type of natural hydrogenase, is capable to heterolytically activate hydrogen molecule and transfer the resulting hydride to an unsaturated substrate, making it a promising hydrogenation catalyst. Over the last three decades, fruitful results on this enzyme have been achieved. In this review, we have summarized the major progresses about this enzyme including its structural characterisation, catalytic mechanism, cofactor biosynthesis, mimetic model development as well as artificial enzymes construction. In the meanwhile, challenges and opportunities of this enzyme and its mimetic systems in the application of synthetic chemistry and others are discussed.

Keywords: [Fe]-hydrogenase; artificial enzyme; biomimetic; cofactor; hydrogenation.

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References

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