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. 2023 May-Jun;49(3):289-305.
doi: 10.1080/0361073X.2022.2095606. Epub 2022 Jul 3.

Time-Varying Effect Models for Examining Age-Dynamic Associations in Gerontological Research

Darcé M Costello  1 , Terrence E Murphy  1
Affiliations

Time-Varying Effect Models for Examining Age-Dynamic Associations in Gerontological Research

Darcé M Costello et al. Exp Aging Res. 2023 May-Jun.

Abstract

Objectives: Dynamic processes unfolding over later adulthood are of prime interest to gerontological researchers. Time-varying effect modeling (TVEM) accommodates dynamic change trajectories, but its use in gerontological research is limited. We introduce and demonstrate TVEM with an empirical example based on the National Health and Aging Trends Study (NHATS).

Methods: We examined (a) age-varying prevalence of past month elevated symptoms of depression and anxiety and (b) age-varying associations between older adults' elevated symptoms of depression and anxiety and needing help with basic activities of daily living and educational attainment.

Results: The proportion of participants reporting elevated symptoms of depression and anxiety in the past month increased gradually from 23-29% across the ages 70-92. Individuals needing help with ADLs had higher odds of reporting elevated symptoms of depression and anxiety, however the association was strongest for those in their 60s versus 80s. Across all ages, adults with lower education levels had higher odds of reporting elevated symptoms of depression and anxiety, an association that also varied by age.

Conclusion: We demonstrated TVEM's value for studying dynamic associations that vary across chronological age. With the recent availability of free, user-friendly software for implementing TVEM, gerontological researchers have a new tool for exploring complex change processes that characterize older adults' development.

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Conflict of interest statement

Conflicts of interest: No conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Estimated prevalence of community-dwelling Medicare beneficiaries reporting past month elevated symptoms of depression and anxiety as a function of age. Dotted lines represent point-wise 95% confidence intervals.
Figure 2.
Figure 2.
TVEM showing the age-varying association between needing any help with basic activities of daily living (BADLs) and past month elevated symptoms of depression and anxiety. Dotted lines represent point-wise 95% confidence intervals.
Figure 3.
Figure 3.
TVEM showing the age-varying association between educational attainment (high school or less vs. post-high school education) and past month elevated symptoms of depression and anxiety. Dotted lines represent point-wise 95% confidence intervals.
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