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. 1987 May;36(3):517-22.
doi: 10.4269/ajtmh.1987.36.517.

Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis

J K Frenkel, A Escajadillo

Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis

J K Frenkel et al. Am J Trop Med Hyg. 1987 May.

Abstract

Seemingly intact cysts and sequential stages of disintegrating cysts of Toxoplasma were identified immunohistologically within developing microglial nodules in a Panamanian night monkey (Aotus lemurinus). This monkey had been successfully immunized and challenged 5 months earlier. This supports the hypothesis that glial nodules unassociated with Toxoplasma tachyzoites may represent the tombstone of a Toxoplasma cyst. Disintegration of cysts may give rise to clinical encephalitis in the presence of apparently adequate immunity.

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