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Randomized Controlled Trial
. 2022 Jul 4;50(9):1225-1229.
doi: 10.1515/jpm-2022-0096. Print 2022 Nov 25.

Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus

Eva Elizabet Camarena Pulido  1   2 , Salvador Mora González  1   2 , América Aime Corona Gutiérrez  1   2 , Mireya Robledo Aceves  3 , Paola Basso Barba  1   2 , Yunuen Salgado Leyva  1
Affiliations
Randomized Controlled Trial

Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus

Eva Elizabet Camarena Pulido et al. J Perinat Med. .

Abstract

Objectives: The frequency of GDM and vitamin D insufficiency in Mexico is high. Vitamin D supplementation in GDM patients has shown favorable but non-homogeneous results regarding improvement of glycemic profile. The aim of the study was to assess the effects of supplementing with 5,000 IU of vitamin D on the glycemic profile of women with GDM.

Methods: A randomized clinical trial was conducted on women with GDM who received 5,000 IU of vitamin D (n=27) or a placebo (n=27) for eight weeks. Changes in vitamin D levels and metabolic parameters before and after the intervention were analyzed.

Results: Vitamin D vs. placebo: 25-OHD (32 vs. 26 ng/mL, p=0.006), HbA1c (6.0 vs. 6.1%, p=0.29), glucose (99 vs. 87 mg/dL, p=0.29), insulin (14 vs. 13 µIU/mL, p=0.79), HOMA-IR (3.6 vs. 2.6, p=0.55), QUICKI (0.31 vs. 0.33, p=0.55).

Conclusions: Supplementation with 5,000 IU of vitamin D for eight weeks had no significant effect on the glycemic profile.

Keywords: gestational diabetes mellitus; randomized clinical trial; vitamin D supplementation.

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