Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jun;33(6):485-490.
doi: 10.5152/tjg.2022.21189.

TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population

Vugar Yagublu  1 , Bayram Bayramov  2 , Melek Yuce  3 , Hazi Aslanov  4
Affiliations

TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population

Vugar Yagublu et al. Turk J Gastroenterol. 2022 Jun.

Abstract

Background: We aimed to evaluate the association between the TP53 Arg72Pro gene polymorphism and risk of colorectal cancer in an Azerbaijani population.

Methods: A total of 141 patients with colorectal cancer and 150 gender- and age-matched controls were involved in the study. The genotypes of the TP53 gene Arg72Pro polymorphism were detected by polymerase chain reaction-based restriction fragment length polymorphism analysis.

Results: We found that the heterozygous genotypes Arg/Pro (odds ratio, 1.128; 95% CI, 0.657-1.937) and mutant Pro/Pro (odds ratio, 1.274; 95% CI, 0.648-2.504) were more frequent in colorectal cancer patients compared to healthy controls. The frequency of the mutant Pro allele (odds ratio, 1.122; 95% CI, 0.809-1.554) was revealed in 47.5% of colorectal cancer patients and in 44.7% of healthy controls. There was no association observed between TP53 Arg72Pro polymorphism and risk of colorectal cancer in an Azerbaijani population (P > .05).

Conclusion: Our findings indicate a lack of relationship between TP53 Arg72Pro polymorphism and risk of colorectal cancer. Furthermore, we have found no statistical differences in the frequency of genotype and allele by sex, age, histological grade, tumor stage, smoking status, and alcohol consumption in this study.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The image of agarose gel electrophoresis which demonstrates the analysis of PCR products of Arg72Pro polymorphism of the P53 gene: lane 1, ladder (100 bp); lanes 2, 5, 6, 7 homozygous mutant Pro/Pro; lane 3, wild-type Arg/Arg; lane 4, heterozygous Arg/Pro.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fan H, Demirci U, Chen P. Emerging organoid models: leaping forward in cancer research. J Hematol Oncol. 2019;12(1):142. 10.1186/s13045-019-0832-4) - DOI - PMC - PubMed
    1. Naccarati A, Polakova V, Pardini B, et al. Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer. Mutagenesis. 2012;27(2):211 218. 10.1093/mutage/ger067) - DOI - PubMed
    1. Gomez-Lazaro M, Fernandez-Gomez FJ, Jordán J. p53: twenty five years understanding the mechanism of genome protection. J Physiol Biochem. 2004;60(4):287 307. 10.1007/BF03167075) - DOI - PubMed
    1. Baugh EH, Ke H, Levine AJ, Bonneau RA, Chan CS. Why are there hotspot mutations in the TP53 gene in human cancers? Cell Death Differ. 2018;25(1):154 160. 10.1038/cdd.2017.180) - DOI - PMC - PubMed
    1. Fischer M. Census and evaluation of p53 target genes. Oncogene. 2017;36(28):3943 3956. 10.1038/onc.2016.502) - DOI - PMC - PubMed