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. 2022 Jun 17;49(4):296-306.
doi: 10.1188/22.ONF.296-306.

Domains of Structured Oral Anticancer Medication Programs: A Scoping Review

Kapeena Sivakumaran  1 , Pamela K Ginex  2 , Haya Waseem  1 , Sarah M Belcher  3 , Sarah Lagler-Clark  1 , Kristine B LeFebvre  2 , Nicole Palmer, Tejanth Pasumarthi  1 , Rebecca L Morgan  4
Affiliations

Domains of Structured Oral Anticancer Medication Programs: A Scoping Review

Kapeena Sivakumaran et al. Oncol Nurs Forum. .

Abstract

Problem identification: An interprofessional approach is necessary to support the multifactorial process of patient adherence to oral anticancer medications (OAMs). This scoping review aims to identify structured OAM programs in published literature, identify components within studies, and propose a framework for institutions developing or maintaining OAM programs.

Literature search: Embase®, PubMed®, and CINAHL® databases were searched for studies published between January 2000 and April 2021.

Data evaluation: Two reviewers screened studies and extracted data. Characteristics and specific domains of the OAM programs were captured. Key components of the programs were identified, and a framework was created to guide program development.

Synthesis: Components identified among the 21 studies were education; counseling; follow-up; dedicated clinician contact; adverse event and toxicity monitoring; adherence monitoring; drug procurement, delivery, and supply; patient- and system-level cost reduction; information technology; and risk assessment.

Implications for research: Based on the findings, a framework for building and evaluating OAM adherence programs is proposed. Future studies should evaluate the reliability and validity of this framework because further testing may lead to the development of additional components.

Keywords: medication adherence; nursing; oncology care; oral anticancer medication; scoping review.

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Figures

FIGURE 1.
FIGURE 1.. PRISMA Flow Diagram
PRISMA—Preferred Reporting Items for Systematic Reviews and Meta-Analyses Note. Two studies used the same oral anticancer medication adherence program (Bordonaro et al., 2012, 2014), so only 20 distinct programs were reported.
FIGURE 2.
FIGURE 2.. Scoping Review Model
See this image and copyright information in PMC

References

    1. Ayanian JZ, & Markel H (2016). Donabedian’s lasting framework for health care quality. New England Journal of Medicine, 375(3), 205–207. 10.1056/NEJMp1605101 - DOI - PubMed
    1. Battis B, Clifford L, Huq M, Pejoro E, & Mambourg S (2017). The impacts of a pharmacist-managed outpatient clinic and chemotherapy-directed electronic order sets for monitoring oral chemotherapy. Journal of Oncology Pharmacy Practice, 23(8), 582–590. 10.1177/1078155216672314 - DOI - PubMed
    1. Bedell CH (2003). A changing paradigm for cancer treatment: The advent of new oral chemotherapy agents. Clinical Journal of Oncology Nursing, 7(6, Suppl.), 5–9. 10.1188/03.CJON.s6.5-9 - DOI - PubMed
    1. Bordonaro S, Raiti F, Di Mari A, Lopiano C, Romano F, Pumo V,… Tralongo P (2012). Active home-based cancer treatment. Journal of Multidisciplinary Healthcare, 2012(5), 137–143. 10.2147/jmdh.S31494 - DOI - PMC - PubMed
    1. Bordonaro S, Romano F, Lanteri E, Cappuccio F, Indorato R, Butera A,… Tralongo P (2014). Effect of a structured, active, home-based cancer-treatment program for the management of patients on oral chemotherapy. Patient Preference and Adherence, 2014(8), 917–923. - PMC - PubMed

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