Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;78(1):95-103.
doi: 10.1007/s12020-022-03126-4. Epub 2022 Jul 4.

Diagnostic and prognostic value of Stanniocalcin 1 expression in papillary thyroid cancer

Sevinç Sengun  1 , Hakan Korkmaz  2 , Metin Ciris  3 , Ramazan Oguz Yüceer  3 , Serife Mehtap Boyluboy  4 , Mehmet Kiran  3
Affiliations

Diagnostic and prognostic value of Stanniocalcin 1 expression in papillary thyroid cancer

Sevinç Sengun et al. Endocrine. 2022 Oct.

Abstract

Purpose: To evaluate the potential role of immunohistochemical changes in stanniocalcin 1 (STC1) and stanniocalcin 2 (STC2) expressions in papillary thyroid cancer (PTC) tissues in the disease's diagnosis and to investigate their relationship with classical clinicopathological prognostic factors.

Methods: The study included 100 patients with PTC. Normal thyroid tissue adjacent to the tumor was taken as the control group. Clinicopathological prognostic features at the time of diagnosis of patients were recorded. STC1 and STC2 expressions of tumor tissue and adjacent normal tissue were determined immunohistochemically.

Results: The sensitivity of STC1 in the diagnosis of PTC was 93%, the specificity was 94%, positive predictive value (PPV) 93.9%, and negative predictive value (NPV) 93.1%. It was determined that the STC1 staining score in tumor tissue was positively correlated with the disease TNM stage score (r = 0.259, p = 0.009) and the increase in STC1 staining score were independent risk factors that increased the risk of lymph node metastasis (R2 = 0.398, p < 0.001). While 21% of the tumor tissues were stained with STC2, none of the normal thyroid tissues adjacent to the tumor tissue showed any staining with STC2. No correlation was found between STC2 immunohistochemical staining of tumor tissue and clinicopathological risk factors for the disease.

Conclusion: Increased STC1 expression in thyroid lesions may be helpful in diagnosing PTC. In addition, since increased STC1 expression in PTC tissues is associated with the risk of lymph node metastasis, it may be an efficient marker for predicting the prognosis of the disease.

Keywords: Diagnosis; Papillary thyroid cancer; Prognosis; STC1; STC2.

PubMed Disclaimer

References

    1. E.L. Mazzaferri, R.T. Kloos, Current approaches to primary therapy for papillary and follicular thyroid cancer. J. Clin. Endocrinol. Metab. 86, 1447–163 (2001) - PubMed
    1. L. Leenhardt, P. Grosclaude, L. Chérié-Challine, Increased incidence of thyroid carcinoma in France: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid 14, 1056–1060 (2004) - PubMed
    1. Z.W. Baloch, V.A. LiVolsi, S.L. Asa, J. Rosai, M.J. Merino, G. Randolph et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference. Diagn. Cytopathol. 36, 425–437 (2008) - PubMed
    1. V.A. LiVolsi, Papillary thyroid carcinoma: an update. Mod. Pathol. 24, 1–9 (2011)
    1. R.A. DeLellis, Pathology and genetics of tumours of endocrine organs, (IARC, 2004), pp. 50–66.

LinkOut - more resources