Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Feb;14(1):79-91.
doi: 10.1007/s13239-022-00632-4. Epub 2022 Jul 5.

A Fluid-Structure Interaction Analysis of Blood Clot Motion in a Branch of Pulmonary Arteries

Fateme Mirakhorli  1 , Bahman Vahidi  2 , Marzieh Pazouki  3 , Pouria Talebi Barmi  1
Affiliations
Case Reports

A Fluid-Structure Interaction Analysis of Blood Clot Motion in a Branch of Pulmonary Arteries

Fateme Mirakhorli et al. Cardiovasc Eng Technol. 2023 Feb.

Abstract

Introduction: Pulmonary embolism (PE) is one of the most prevalent diseases amid hospitalized patients taking many people's lives annually. This phenomenon, however, has not been investigated via numerical simulations.

Methods: In this study, an image-based model of pulmonary arteries has been constructed from a 44-year-old man's computed tomography images. The fluid-structure interaction method was used to simulate the motion of the blood clot. In this regard, Navier-Stokes equations, as the governing equations, have been solved in an arbitrary Lagrangian-Eulerian (ALE) formulation.

Results: According to our results, the velocity of visco-hyperelastic model of the emboli was relatively higher than the emboli with hyperelastic model, despite their similar behavioral pattern. The stresses on the clot were also investigated and showed that the blood clot continuously sustained stresses greater than 165 Pa over an about 0.01 s period, which can cause platelets to leak and make the clot grow or tear apart.

Conclusions: It could be concluded that in silico analysis of the cardiovascular diseases initiated from clot motion in blood flow is a valuable tool for a better understanding of these phenomena.

Keywords: Biofluids; Finite element method (FEM); Fluid-structure interaction (FSI); Pulmonary embolism (PE); Venous blood clot.

PubMed Disclaimer

References

    1. Abolfazli, E., N. Fatouraee, and B. Vahidi. Dynamics of motion of a clot through an arterial bifurcation: a finite element analysis. Fluid Dyn. Res. 46(5):055505–055505, 2014. https://doi.org/10.1088/0169-5983/46/5/055505 . - DOI
    1. Akhtar, S. Fat embolism. Anesthesiol. Clin. 27(3):533–550, 2009. https://doi.org/10.1016/j.anclin.2009.07.018 . - DOI - PubMed
    1. Al, L. E. Harrison's Principles of Internal Medicine, 19th. 2015, pp. 857–861.
    1. Aldosari, S., S. Jansen, and Z. Sun. Patient-specific 3D printed pulmonary artery model with simulation of peripheral pulmonary embolism for developing optimal computed tomography pulmonary angiography protocols. Quant. Imaging Med. Surg. 9(1):75, 2019. https://doi.org/10.3390/fluids4040190 . - DOI - PubMed - PMC
    1. Aleman, M. M., B. L. Walton, J. R. Byrnes, and A. S. Wolberg. Fibrinogen and red blood cells in venous thrombosis. Thromb. Res. 133(SUPPL. 1):S38–S40, 2014. https://doi.org/10.1016/j.thromres.2014.03.017 . - DOI - PubMed - PMC

Publication types

LinkOut - more resources