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. 2022 Oct;58(10):1811-1815.
doi: 10.1111/jpc.16110. Epub 2022 Jul 5.

Neurodevelopmental outcomes in neonatal extracorporeal membrane oxygenation survivors: An institutional perspective

Ashfaque Quadir  1   2 , Himanshu Popat  2   3 , Cathryn Crowle  2   3 , Claire Galea  3 , Jia Y Chong  4 , Chong T Goh  1   2
Affiliations

Neurodevelopmental outcomes in neonatal extracorporeal membrane oxygenation survivors: An institutional perspective

Ashfaque Quadir et al. J Paediatr Child Health. 2022 Oct.

Abstract

Aim: To describe the neurodevelopmental outcomes following extracorporeal membrane oxygenation (ECMO) in early infancy.

Methods: Thirty-seven patients who had survived following ECMO support from 2008 to 2018 had their neurodevelopmental outcomes assessed and analysed using the Bayley Scales of Infant and Toddler Development. Developmental outcome was defined as impairment in any of the developmental domains of motor function, cognition and language with mild impairment being 1-2 standard deviations below the test mean, moderate being 2-3 standard deviations below and severe being greater than 3 standard deviations below.

Results: Of these 37 patients, the median age at admission to Paediatric Intensive Care Unit was 0.4 months (interquartile range 2.8 months) with all of the study patients having an underlying diagnosis of congenital cardiac disease and 37/40 (92.5%) ECMO runs occurring in the immediate post-operative period. Of the 29 patients who had had follow-up at 12 months of age or older, 3 (10.3%) had severe impairment, 4 (13.8%) had moderate impairment, 12 (41.3%) had mild impairment and 10 (34.5%) had no impairment. Gross motor function was most significantly impacted in 18/29 (62.1%) patients, of which 7/18 (38.9%) had severe impairment. This was followed by impairment of receptive language in 8/29 (27.6%) patients and expressive language in 6/29 (20.1%) patients.

Conclusions: One in four infants undergoing ECMO treatment in early infancy has moderate to severe neurodevelopmental impairment. Gross motor and language are the most affected developmental domains.

Keywords: ECMO; developmental; neurodevelopment; outcomes.

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References

    1. Roeleveld PP, Mendonca MH. Neonatal cardiac ECMO in 2019 and beyond. Front. Pediatr. 2019; 7: 327.
    1. Boyle K, Felling R, Yiu A et al. Neurologic outcomes after extracorporeal membrane oxygenation-A systematic review. Pediatr. Crit. Care Med. 2018; 19: 760-6.
    1. Hamrick SE, Gremmels DB, Keet CA et al. Neurodevelopmental outcome of infants supported with extracorporeal membrane oxygenation after cardiac surgery. Pediatrics 2003; 111: e671-e5.
    1. Wray J, Kakat S, Brown K, O'Callaghan M, Thiruchelvam T, Hoskote A. Childhood extracorporeal membrane oxygenation survivors: Parents highlight need for structured follow-up and support after hospital discharge. Pediatr. Crit. Care Med. 2020; 21: 461-8.
    1. International Summary: Extracorporeal Life Support Organization (ELSO); 2021 [updated April 2021].

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