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Case Reports
. 2022:18:100336.
doi: 10.1016/j.lrr.2022.100336. Epub 2022 Jun 30.

Spontaneous remission of chronic lymphocytic leucemia in a patient with SARS-CoV2

Hale Bülbül  1 , Hamza Ekmel Nazlı  2 , Aybüke Olgun  1 , Alper Togay  3 , Dudu Solakoğlu Kahraman  4
Affiliations
Case Reports

Spontaneous remission of chronic lymphocytic leucemia in a patient with SARS-CoV2

Hale Bülbül et al. Leuk Res Rep. 2022.

Abstract

Although novel therapies have improved the treatment outcome of patients, chronic lymphocytic leukaemia (CLL) is still considered incurable. Recently, a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), causing coronavirus disease 2019 (Covid 19), emerged in late 2019, and it has posed a global health threat. In a limited number of cases, it has been shown that some lymphoma types spontaneously regress after SARS-CoV2 infection suggesting that the infection can trigger de immune system against the tumour cell. Cross-reactivity of pathogen-specific T cells with tumour antigens and natural killer cell activation can be the possible mechanism of this hypothesis.

Keywords: Chronic lymphocytic leukaemia; SARS-CoV2; Spontaneous remission.

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Conflict of interest statement

The authors declare no conflicts of interest

Figures

Fig 1
Fig. 1
(a) shows the flow cytometry at the time of admission. Proliferation of monotypic B lymphocytes, which constitute 89% of lymphocytes and display CD19+, CD 20+, CD22+, CD5+, CD23+, HLA DR+, immunophenotypes, was detected. (b) shows the flow cytometry 1 year after discharge. Proliferation of monotypic B lymphocytes which compatible with CLL, was not detected.
Fig 2
Fig. 2
(a) Multiple enlarged lymphadenopathies, the largest of which was 30 × 17 mm in mediastinum. (b) PET CT revealed regression of mediastinal lymphadenopathies, after recovery of Covid 19. (c) CD4+ T lymphocyte infiltration in bone marrow. (d) CD8+ T lymphocyte infiltration in bone marrow. (e) leukocyte graph.
See this image and copyright information in PMC

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