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Review
. 2022 Jun;87(6):548-558.
doi: 10.1134/S0006297922060062.

Structurally Modified Plant Viruses and Bacteriophages with Helical Structure. Properties and Applications

Olga A Kondakova  1 , Ekaterina A Evtushenko  2 , Oleg A Baranov  1 , Nikolai A Nikitin  1 , Olga V Karpova  1
Affiliations
Review

Structurally Modified Plant Viruses and Bacteriophages with Helical Structure. Properties and Applications

Olga A Kondakova et al. Biochemistry (Mosc). 2022 Jun.

Abstract

Structurally modified virus particles can be obtained from the rod-shaped or filamentous virions of plant viruses and bacteriophages by thermal or chemical treatment. They have recently attracted attention of the researchers as promising biogenic platforms for the development of new biotechnologies. This review presents data on preparation, structure, and properties of the structurally modified virus particles. In addition, their biosafety for animals is considered, as well as the areas of application of such particles in biomedicine. A separate section is devoted to one of the most relevant and promising areas for the use of structurally modified plant viruses - design of vaccine candidates based on them.

Keywords: bacteriophages; biomedicine; biotechnology; plant viruses; spherical particles; structurally modified viruses; vaccines.

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Conflict of interest statement

The authors declare no conflicts of interest in the financial or other sphere. This article does not contain any studies with human participants or animals performed by any of the authors.

Figures

Fig. 1.
Fig. 1.
Structurally modified particles generated by thermally-induced rearrangement of TMV virions. a) TMV, transmission electron microscopy, contrasting with 2% uranyl acetate, scale bar 200 nm; b) TMV SPs, transmission electron microscopy, scale bar 2 µm. Images were obtained at the Department of Virology, Faculty of Biology, Lomonosov Moscow State University.
Fig. 2.
Fig. 2.
Possible areas of application of TMV SPs.
Fig. 3.
Fig. 3.
Possible areas of application of M13 SPs.
See this image and copyright information in PMC

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