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Clinical Trial
. 2022 Dec;37(12):2049-2058.
doi: 10.1007/s00380-022-02108-w. Epub 2022 Jul 5.

Declines in serum uric acid level after catheter ablation of atrial fibrillation

Daisetsu Aoyama  1 , Hiroyasu Uzui  2 , Takayuki Sekihara  2 , Tomoya Eguchi  2 , Kanae Hasegawa  2 , Toshihiko Tsuji  2 , Tatsuhiro Kataoka  2 , Moeko Nagao  2 , Shota Kakehashi  2 , Moe Mukai  2 , Takayoshi Aiki  2 , Junya Yamaguchi  2 , Yuichiro Shiomi  2 , Naoto Tama  2 , Yoshitomo Fukuoka  2 , Kentaro Ishida  2 , Hiroshi Tada  2
Affiliations
Clinical Trial

Declines in serum uric acid level after catheter ablation of atrial fibrillation

Daisetsu Aoyama et al. Heart Vessels. 2022 Dec.

Abstract

Background: Few studies have examined whether catheter ablation for AF patients improves biomarkers other than serum levels of brain natriuretic peptide (BNP) and renal function. This study was to explore whether catheter ablation for atrial fibrillation (AF) patients affects uric acid (UA), glucose and lipid metabolism.

Methods and results: A total of 206 patients (66.6 ± 10.4 years; 132 men) who underwent initial AF ablation without changes to oral medications were included. Baseline BNP and UA levels significantly decreased at 1 year after ablation (p < 0.05 each). Changes in UA level correlated significantly with pre-procedural UA level (r = 0.57). In multivariable logistic regression modeling, pre-procedural UA level, persistent AF, and hemoglobin A1c (p < 0.05 each) were independent predictors of post-procedural UA level decline. Significant improvements in both persistent and paroxysmal AF patients were identified, and the magnitude of post-procedural serum UA level decline after ablation (ΔUA) was significantly greater in patients with persistent AF (0.8 ± 1.0 mg/dl) than in those with paroxysmal AF (0.2 ± 0.8 mg/dl, p < 0.001). Of the 48 patients with high UA level before procedure, 28 patients showed improvement in UA level to normal range.

Conclusions: Catheter ablation for AF patients significantly improved serum UA levels without obvious influences of heart failure, renal function, or inflammation, suggesting that AF ablation may be effective for AF patients with hyperuricemia. Trial registration The study was approved by the Research Ethics Committee of University of Fukui (no. 20210132) and clinical trial registration (UMIN000044669).

Keywords: Atrial fibrillation; Catheter ablation; Uric acid.

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